Laboratory of Cell Physiology and Pharmacology, Center for Study and Therapy of Pain, Gr. T. Popa University of Medicine and Pharmacy, 16 Universitatii Str., 700115, Iasi, Romania.
Pflugers Arch. 2010 May;459(6):787-92. doi: 10.1007/s00424-010-0805-5. Epub 2010 Mar 7.
Endothelium-dependent changes in vasomotor tone, whether evoked by vasoactive agents or physical forces, are recognized as essential for the local hemodynamic control in various normal and pathological circumstances. They are based on a complex signaling network within the vascular wall. In recent years, substantial efforts have been made to analyze how such signals are generated and used in the endothelium-dependent control of vascular smooth muscle. The underlying mechanisms vary with species, age, sex, hormonal status, vascular bed studied, caliber of the blood vessels, triggering stimuli, pre-existing vascular tone, oxidative stress, and pathology. Such aspects and many others will be addressed specifically by the authors contributing to this volume.
血管舒缩张力的内皮依赖性变化，无论是由血管活性物质还是物理力引起的，都被认为是各种正常和病理情况下局部血液动力学控制的基础。它们基于血管壁内的一个复杂信号网络。近年来，人们做出了巨大的努力来分析这些信号是如何在血管内皮依赖性控制血管平滑肌中产生和使用的。潜在的机制因物种、年龄、性别、激素状态、研究的血管床、血管的口径、触发刺激、预先存在的血管张力、氧化应激和病理而异。本书的作者将专门讨论这些方面和许多其他方面。
