Farouk M, Niotis M, Branum G D, Cotton P B, Meyers W C
Department of Surgery, Duke University Medical Center, Durham, NC 27710.
Arch Surg. 1991 May;126(5):650-2. doi: 10.1001/archsurg.1991.01410290128026.
Local resection of tumors of the papilla of Vater was performed in six cases (three benign adenomas and three adenocarcinomas). Pathology was suggested in all cases by endoscopic biopsy and confirmed by operative excision. A method of excision of the tumor and reconstruction of the pancreaticobiliary apparatus was used that eliminated all gross and microscopic disease. Only one of the patients with benign disease (familial polyposis) suffered from local recurrence. All three patients with malignant tumors developed local recurrences within 2 years of resection. Local resection seems to be a viable alternative to Whipple's resection in patients with benign tumors. In malignant cases, local resection should be considered only a palliative procedure and confined to elderly patients with severe concomitant disease and patients in whom a more radical procedure would incur an undue surgical risk.
对6例 Vater 乳头肿瘤进行了局部切除(3例为良性腺瘤,3例为腺癌)。所有病例均经内镜活检提示病理诊断,并经手术切除证实。采用了一种肿瘤切除及胰胆管重建的方法,消除了所有肉眼可见和显微镜下可见的病变。仅1例良性疾病(家族性息肉病)患者出现局部复发。所有3例恶性肿瘤患者在切除后2年内均发生局部复发。对于良性肿瘤患者,局部切除似乎是 Whipple 手术的一种可行替代方法。在恶性病例中,局部切除仅应被视为一种姑息性手术,仅限于伴有严重合并症的老年患者以及进行更根治性手术会带来过高手术风险的患者。