构建捷克人群大型Y染色体短串联重复序列单倍型数据库并研究其亚结构。
Assembly of a large Y-STR haplotype database for the Czech population and investigation of its substructure.
作者信息
Zastera Jan, Roewer Lutz, Willuweit Sascha, Sekerka Patrik, Benesova Lucie, Minarik Marek
机构信息
Laboratory for Molecular Genetics and Oncology, Genomac International, Ltd., Prague, Czech Republic.
出版信息
Forensic Sci Int Genet. 2010 Apr;4(3):e75-8. doi: 10.1016/j.fsigen.2009.06.005.
Twelve Y-chromosomal short tandem repeats (Y-STR) (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a, DYS385b, DYS437, DYS438, and DYS439) included in the PowerPlex Y Kit (Promega Corporation, Madison, USA) were studied for 1750 unrelated males living in 14 regions of the Czech Republic. A total of 1148 different haplotypes were found. The overall haplotype diversity (HD) was determined as 0.998. Analysis of Molecular Variance (AMOVA) reveals non-significant distances between regions concerning their haplotype distribution, thus allowing to use the whole sample as a representative reference database of the Czech Republic. Median network analysis shows a remarkable bipartite composition of the Czech haplotypes, falling in distinct clusters with Eastern and Western European roots.
对Promega公司（美国麦迪逊）的PowerPlex Y试剂盒中包含的12个Y染色体短串联重复序列（Y-STR）（DYS19、DYS389I、DYS389II、DYS390、DYS391、DYS392、DYS393、DYS385a、DYS385b、DYS437、DYS438和DYS439）进行了研究，研究对象为居住在捷克共和国14个地区的1750名无血缘关系的男性。共发现1148种不同的单倍型。确定总体单倍型多样性（HD）为0.998。分子方差分析（AMOVA）显示，各地区之间在单倍型分布方面的差异不显著，因此可以将整个样本用作捷克共和国的代表性参考数据库。中位数网络分析显示，捷克单倍型具有显著的二分组成，分为具有东欧和西欧根源的不同簇。
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