Zhu Zheng-Fei, Fan Min, Fu Xiao-Long
Department of Radiation Oncology, Fudan University Cancer Hospital, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Onkologie. 2010;33(3):107-9. doi: 10.1159/000277672. Epub 2010 Feb 22.
Radiation recall dermatitis (RRD) is an inflammatory skin reaction in a previously irradiated field in response to certain pharmacological agents. Little is known about the potential risk of RRD in response to the use of vinorelbine and cisplatin.
Herein, we report a case of RRD following the combination treatment of vinorelbine and cisplatin in a lung cancer patient with lymph node metastasis. We describe the timing and doses of radiation exposure and chemotherapy, the features of the skin reactions, the clinical management, and the outcome. We also review previous reports on RRD to explain the characteristics of the reaction and the potential mechanisms.
Clinical health care professionals should be aware of the possibility of a recall reaction whenever vinorelbine and cisplatin are used, although the frequency is probably low.
放射性回忆性皮炎（RRD）是指先前接受过放射治疗的部位，在接触某些药物制剂后发生的一种炎症性皮肤反应。对于使用长春瑞滨和顺铂引发RRD的潜在风险，人们了解甚少。
在此，我们报告1例伴有淋巴结转移的肺癌患者在接受长春瑞滨和顺铂联合治疗后发生RRD的病例。我们描述了放射暴露和化疗的时间及剂量、皮肤反应特征、临床处理情况及结果。我们还回顾了既往关于RRD的报告，以阐释该反应的特点及潜在机制。
临床医护人员应意识到，无论何时使用长春瑞滨和顺铂，均有可能发生回忆反应，尽管其发生率可能较低。
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