Department of Radiation Oncology, AZ Groeninge Hospital, Loofstraat 43, 8500, Kortrijk, Belgium,
Strahlenther Onkol. 2014 Aug;190(8):762-6. doi: 10.1007/s00066-014-0632-2. Epub 2014 Apr 4.
The radiation recall reaction (RRR) is an inflammatory reaction that occurs in previously irradiated areas. The phenomenon is probably due to an idiosyncratic hypersensitivity reaction, in which a second agent can recall the inflammatory reaction.
This case report documents a cold-weather-induced radiation recall dermatitis (RRD). We observed a severe RRD in a patient after chemoradiotherapy treatment with cisplatin for a nasopharyngeal carcinoma, precipitated by cold temperatures, which developed 9 days after completion of therapy. In the medical literature, RRD following extreme cold temperatures seems to be a peculiar event.
Until further information on the interaction is available, future studies on combined chemotherapy with cisplatin should be carefully monitored and any side effects clearly documented. This case suggests that environmental conditions may play a contributing role in the development of RRD. This case also implies that neither fraction size nor total radiation dose is a determining factor in the development of the dermatologic reaction.
放射性回忆反应（RRR）是一种在先前接受过放射治疗的区域发生的炎症反应。这种现象可能是由于一种特发性过敏反应，其中第二种药物可以引起炎症反应。
本病例报告记录了一例寒冷天气引起的放射性回忆性皮炎（RRD）。我们观察到一名鼻咽癌患者在接受顺铂化疗和放疗后，在治疗完成后 9 天，因寒冷天气而出现严重的 RRD。在医学文献中，极冷温度下的 RRD 似乎是一种特殊事件。
在获得有关相互作用的进一步信息之前，应仔细监测联合顺铂化疗的未来研究，并明确记录任何副作用。本病例表明，环境条件可能在 RRD 的发展中起作用。本病例还表明，分次剂量大小或总辐射剂量都不是皮肤反应发展的决定因素。
