β-内酰胺抗生素抑制大鼠吗啡身体依赖性的发展。
beta-Lactam antibiotic inhibits development of morphine physical dependence in rats.
作者信息
Rawls Scott M, Baron David A, Kim Jae
机构信息
Department of Pharmaceutical Sciences, Temple University Health Sciences Center, Philadelphia, Pennsylvania 1914, USA.
出版信息
Behav Pharmacol. 2010 Mar;21(2):161-4. doi: 10.1097/FBP.0b013e328337be10.
Abstract
beta-Lactam antibiotics enhance cellular glutamate uptake. As increased glutamatergic transmission is a primary mediator of opiate dependence, we tested the hypothesis that a beta-lactam antibiotic (ceftriaxone) prevents development of morphine physical dependence in rats. Morphine (20 mg/kg) was injected twice daily for 10 days to induce physical dependence. Naloxone (10 mg/kg) administration 1, 48, and 96 h after the last morphine injection induced a withdrawal syndrome characterized by the appearance of wet-dog shakes, teeth chattering, eye blinking, jumping, and paw tremor. Ceftriaxone (150, 200 mg/kg) injected once daily during chronic morphine exposure inhibited each naloxone-precipitated withdrawal sign. Ceftriaxone efficacy persisted even after the 96 h-naloxone (10 mg/kg) injection. These results suggest that beta-lactam antibiotics inhibit processes leading to development of morphine physical dependence.
摘要
β-内酰胺类抗生素可增强细胞对谷氨酸的摄取。由于谷氨酸能传递增加是阿片类药物依赖的主要介导因素，我们检验了以下假设：β-内酰胺类抗生素（头孢曲松）可预防大鼠吗啡身体依赖性的形成。每天两次注射吗啡（20mg/kg），持续10天以诱导身体依赖性。在最后一次注射吗啡后1、48和96小时给予纳洛酮（10mg/kg），诱发戒断综合征，其特征为出现湿狗样抖动、牙齿打颤、眨眼、跳跃和爪部震颤。在慢性吗啡暴露期间每天注射一次头孢曲松（150、200mg/kg）可抑制每种纳洛酮诱发的戒断症状。即使在注射96小时的纳洛酮（10mg/kg）后，头孢曲松的疗效仍然持续。这些结果表明，β-内酰胺类抗生素可抑制导致吗啡身体依赖性形成的过程。
相似文献
1
beta-Lactam antibiotic inhibits development of morphine physical dependence in rats.β-内酰胺抗生素抑制大鼠吗啡身体依赖性的发展。
Behav Pharmacol. 2010 Mar;21(2):161-4. doi: 10.1097/FBP.0b013e328337be10.
2
Matricaria chamomilla extract inhibits both development of morphine dependence and expression of abstinence syndrome in rats.母菊花提取物可抑制大鼠吗啡依赖的形成及戒断综合征的表现。
J Pharmacol Sci. 2003 May;92(1):50-5. doi: 10.1254/jphs.92.50.
3
Continuous co-administration of dextromethorphan or MK-801 with morphine: attenuation of morphine dependence and naloxone-reversible attenuation of morphine tolerance.右美沙芬或MK-801与吗啡连续联合给药：减轻吗啡依赖性以及纳洛酮可逆性减轻吗啡耐受性。
Pain. 1996 Sep;67(1):79-88. doi: 10.1016/0304-3959(96)81972-5.
4
Glycyl-glutamine, an endogenous beta-endorphin-derived peptide, inhibits morphine-induced conditioned place preference, tolerance, dependence, and withdrawal.甘氨酰谷氨酰胺，一种内源性β-内啡肽衍生肽，可抑制吗啡诱导的条件性位置偏爱、耐受性、依赖性和戒断反应。
J Pharmacol Exp Ther. 2005 Nov;315(2):949-58. doi: 10.1124/jpet.105.091553. Epub 2005 Aug 3.
5
Height-dependent difference in the expression of naloxone-induced withdrawal jumping behavior in morphine dependent rats.吗啡依赖大鼠纳洛酮催促戒断跳跃行为表达的身高依赖性差异。
Neurosci Lett. 2012 May 2;515(2):174-6. doi: 10.1016/j.neulet.2012.03.047. Epub 2012 Mar 24.
6
The effect of the glycine/NMDA receptor antagonist, (+)-HA966, on morphine dependence in neuropathic rats.甘氨酸/N-甲基-D-天冬氨酸受体拮抗剂（+）-HA966对神经性大鼠吗啡依赖的影响。
Neuropharmacology. 2000 Jul 10;39(9):1589-95. doi: 10.1016/s0028-3908(99)00236-1.
7
Focal kappa-opioid receptor-mediated dependence and withdrawal in the nucleus paragigantocellularis.孤束旁核中κ-阿片受体介导的局灶性依赖和戒断反应
Pharmacol Biochem Behav. 2002 Dec;74(1):241-52. doi: 10.1016/s0091-3057(02)00993-0.
8
Ethopharmacological analysis of naloxone-precipitated morphine withdrawal syndrome in rats: a newly-developed "etho-score".大鼠中纳洛酮诱发的吗啡戒断综合征的行为药理学分析：一种新开发的“行为评分”
Psychopharmacology (Berl). 1995 Nov;122(2):122-30. doi: 10.1007/BF02246086.
9
Chronic naloxone-induced supersensitivity affects neither tolerance to nor physical dependence on morphine at hypothalamus-pituitary-adrenocortical axis.长期纳洛酮诱导的超敏反应对下丘脑-垂体-肾上腺皮质轴上吗啡的耐受性和身体依赖性均无影响。
Neuropeptides. 1996 Feb;30(1):29-36. doi: 10.1016/s0143-4179(96)90051-7.
10
Effects of harman and harmine on naloxone-precipitated withdrawal syndrome in morphine-dependent rats.哈尔满和骆驼蓬碱对吗啡依赖大鼠纳洛酮诱发戒断综合征的影响。
Life Sci. 2003 Sep 19;73(18):2363-71. doi: 10.1016/s0024-3205(03)00647-7.
引用本文的文献
1
Differential Effects of Intrahippocampal Administration of Ceftriaxone on Morphine Dependence and Withdrawal Syndrome in Rats.海马内注射头孢曲松对大鼠吗啡依赖和戒断综合征的不同影响
ACS Omega. 2024 Oct 10;9(42):42895-42904. doi: 10.1021/acsomega.4c05331. eCollection 2024 Oct 22.
2
Clavulanic acid inhibits methamphetamine locomotor sensitization in mice and normalizes methamphetamine-induced changes in glutaminase mRNA levels in the nucleus accumbens.克拉维酸抑制了小鼠的安非他命运动敏化作用，并使安非他命引起的伏隔核谷氨酰胺酶 mRNA 水平变化恢复正常。
Physiol Behav. 2024 Oct 1;284:114646. doi: 10.1016/j.physbeh.2024.114646. Epub 2024 Jul 23.
3
Ceftriaxone as a Novel Therapeutic Agent for Hyperglutamatergic States: Bridging the Gap Between Preclinical Results and Clinical Translation.头孢曲松作为治疗高谷氨酸能状态的新型治疗药物：弥合临床前研究结果与临床转化之间的差距
Front Neurosci. 2022 Jul 5;16:841036. doi: 10.3389/fnins.2022.841036. eCollection 2022.
4
Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight.肠道微生物组对物质使用障碍的调节作用的证据：显而易见却被忽视。
Pharmacol Rev. 2021 Apr;73(2):571-596. doi: 10.1124/pharmrev.120.000144.
5
Non-Opioid Treatments for Opioid Use Disorder: Rationales and Data to Date.阿片类药物使用障碍的非阿片类药物治疗：基本原理和现有数据。
Drugs. 2020 Oct;80(15):1509-1524. doi: 10.1007/s40265-020-01373-1.
6
Glial mechanisms underlying substance use disorders.物质使用障碍背后的神经胶质机制。
Eur J Neurosci. 2019 Aug;50(3):2574-2589. doi: 10.1111/ejn.14163. Epub 2018 Oct 22.
7
Synthetic cathinone MDPV downregulates glutamate transporter subtype I (GLT-1) and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator.合成卡西酮MDPV下调谷氨酸转运体亚型I（GLT-1），并产生奖赏和运动激活效应，而GLT-1激活剂可减弱这些效应。
Neuropharmacology. 2016 Sep;108:111-9. doi: 10.1016/j.neuropharm.2016.04.014. Epub 2016 Apr 13.
8
Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease.谷氨酸转运体EAAT2：调节、功能及其作为神经和精神疾病治疗靶点的潜力
Cell Mol Life Sci. 2015 Sep;72(18):3489-506. doi: 10.1007/s00018-015-1937-8. Epub 2015 Jun 2.
9
Glutamate Transporter GLT-1 as a Therapeutic Target for Substance Use Disorders.谷氨酸转运体GLT-1作为物质使用障碍的治疗靶点
CNS Neurol Disord Drug Targets. 2015;14(6):745-56. doi: 10.2174/1871527314666150529144655.
10
Effect of ceftriaxone and topiramate treatments on naltrexone-precipitated morphine withdrawal and glutamate receptor desensitization in the rat locus coeruleus.头孢曲松和托吡酯治疗对大鼠蓝斑中纳曲酮诱发的吗啡戒断及谷氨酸受体脱敏的影响。
Psychopharmacology (Berl). 2015 Aug;232(15):2795-809. doi: 10.1007/s00213-015-3913-2. Epub 2015 Mar 20.
本文引用的文献
1
The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats.β-内酰胺类抗生素头孢曲松可减轻大鼠吗啡诱发的体温过高。
Br J Pharmacol. 2007 Aug;151(7):1095-102. doi: 10.1038/sj.bjp.0707309. Epub 2007 Jun 25.
2
Neuroprotective potential of ceftriaxone in in vitro models of stroke.头孢曲松在中风体外模型中的神经保护潜力。
Neuroscience. 2007 May 11;146(2):617-29. doi: 10.1016/j.neuroscience.2007.02.003. Epub 2007 Mar 23.
3
Pharmacological Induction of Ischemic Tolerance by Glutamate Transporter-1 (EAAT2) Upregulation.通过上调谷氨酸转运体-1（EAAT2）进行缺血耐受的药理学诱导。
Stroke. 2007 Jan;38(1):177-82. doi: 10.1161/01.STR.0000252091.36912.65. Epub 2006 Nov 22.
4
The excitatory amino acid transporters: pharmacological insights on substrate and inhibitor specificity of the EAAT subtypes.兴奋性氨基酸转运体：关于EAAT亚型底物和抑制剂特异性的药理学见解
Pharmacol Ther. 2005 Sep;107(3):271-85. doi: 10.1016/j.pharmthera.2005.01.002. Epub 2005 Apr 14.
5
Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.β-内酰胺类抗生素通过增加谷氨酸转运体的表达来提供神经保护作用。
Nature. 2005 Jan 6;433(7021):73-7. doi: 10.1038/nature03180.
6
Involvement of glial glutamate transporters in morphine dependence.胶质细胞谷氨酸转运体在吗啡依赖中的作用
Ann N Y Acad Sci. 2004 Oct;1025:383-8. doi: 10.1196/annals.1307.047.
7
Opiate physical dependence and N-methyl-D-aspartate receptors.阿片类物质身体依赖性与N-甲基-D-天冬氨酸受体
Eur J Pharmacol. 2004 Oct 1;500(1-3):121-8. doi: 10.1016/j.ejphar.2004.07.017.
8
The role of AMPA and metabotropic glutamate receptors on morphine withdrawal in infant rats.AMPA和代谢型谷氨酸受体在幼鼠吗啡戒断中的作用
Int J Dev Neurosci. 2004 Aug-Oct;22(5-6):379-95. doi: 10.1016/j.ijdevneu.2004.06.005.
9
Effect of gene transfer of GLT-1, a glutamate transporter, into the locus coeruleus by recombinant adenoviruses on morphine physical dependence in rats.重组腺病毒介导谷氨酸转运体GLT-1基因转入大鼠蓝斑对吗啡身体依赖性的影响
Eur J Neurosci. 2004 Jan;19(1):221-6. doi: 10.1111/j.1460-9568.2004.03101.x.
10
Inhibition of morphine tolerance and dependence by MS-153, a glutamate transporter activator.谷氨酸转运体激活剂MS-153对吗啡耐受性和依赖性的抑制作用
Eur J Pharmacol. 2001 May 4;419(1):39-45. doi: 10.1016/s0014-2999(01)00965-7.
Zotero 插件