氟代脱氧葡萄糖正电子发射断层扫描-计算机断层扫描在宫颈癌中的应用：原发性肿瘤氟代脱氧葡萄糖摄取与转移潜能之间的关系

FDG PET-CT in cervical cancer: relationship between primary tumor FDG uptake and metastatic potential.

作者信息

Yilmaz Mustafa, Adli Mustafa, Celen Zeki, Zincirkeser Sabri, Dirier Ahmet

机构信息

Department of Nuclear Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey.

出版信息

Nucl Med Commun. 2010 Jun;31(6):526-31. doi: 10.1097/MNM.0b013e32833800e7.

DOI:10.1097/MNM.0b013e32833800e7

PMID:20215979

Abstract

OBJECTIVE

We retrospectively evaluated the relationships between primary tumor F-fluorodeoxyglucose (FDG) uptake measured as the maximum standardized uptake value (SUV(max)) and local extension, and nodal or distant metastasis in patients with cervical cancer on pretreatment FDG positron emission tomography-computed tomography (PET-CT).

METHODS

Forty-three patients (mean age, 55.14 years; range, 34-90 years) with cervical cancer who underwent FDG PET-CT scans for staging before the initiation of treatment were included in the study. Primary tumor SUV(max) was calculated; clinical tumor stages, presence of local extension, sites of lymph node and distant organ metastases were recorded. The patients were divided into low and high SUV groups by using the median primary tumor SUV(max). The low SUV group consisted of 21 patients with SUV(max) less than 13.5, the high SUV group consisted of 22 patients with SUV(max) > or = 13.5. Their data were compared statistically.

RESULTS

The average SUV(max) was 9.6+/-2.6 and 19.9+/-4.9 in the low and high SUV groups, respectively. In the low SUV group, six patients (29%) had a local extension, eight (38%) had pelvic and/or para-aortic lymph node metastasis, and one had distant organ metastasis (4.7%). In the high SUV group, 10 patients (45%) had a local extension, 16 (73%) had pelvic and/or para-aortic lymph node metastasis, and two (9%) had distant organ metastases. There was a significant difference in the lymph node metastasis rate between the two groups (P<0.05), but differences in local extension and distant organ metastasis were not statistically significant (P>0.05). In addition, there was a moderate correlation between SUV(max) and clinical tumor stages (r=0.40, P=0.0075).

CONCLUSION

Higher primary tumor FDG uptake predicts higher nodal metastatic potential in cervical cancer patients. Patients with higher SUV(max) in cervical tumor may need a close follow-up because of their higher metastatic potential.

摘要

目的

我们回顾性评估了在治疗前氟代脱氧葡萄糖（FDG）正电子发射断层扫描-计算机断层扫描（PET-CT）检查中，以最大标准化摄取值（SUV(max)）衡量的宫颈癌原发肿瘤FDG摄取与局部扩展、淋巴结或远处转移之间的关系。

方法

本研究纳入了43例宫颈癌患者（平均年龄55.14岁；范围34 - 90岁），这些患者在开始治疗前接受了FDG PET-CT扫描以进行分期。计算原发肿瘤的SUV(max)；记录临床肿瘤分期、局部扩展情况、淋巴结和远处器官转移部位。以原发肿瘤SUV(max)的中位数将患者分为低SUV组和高SUV组。低SUV组由21例SUV(max)小于13.5的患者组成，高SUV组由22例SUV(max)≥13.5的患者组成。对两组数据进行统计学比较。

结果

低SUV组和高SUV组的平均SUV(max)分别为9.6±2.6和19.9±4.9。在低SUV组中，6例患者（29%）有局部扩展，8例（38%）有盆腔和/或腹主动脉旁淋巴结转移，1例有远处器官转移（4.7%）。在高SUV组中，10例患者（45%）有局部扩展，16例（73%）有盆腔和/或腹主动脉旁淋巴结转移，2例（9%）有远处器官转移。两组之间淋巴结转移率有显著差异（P<0.05），但局部扩展和远处器官转移的差异无统计学意义（P>0.05）。此外，SUV(max)与临床肿瘤分期之间存在中度相关性（r = 0.40，P = 0.0075）。