Department of Pediatrics, University of Colorado Denver School of Medicine, The Children's Hospital, Aurora, CO, USA.
Pediatr Crit Care Med. 2010 Mar;11(2 Suppl):S41-5. doi: 10.1097/PCC.0b013e3181d10845.
The prostacyclins-prostanoids were one of the first medications used to treat pulmonary arterial hypertension (PAH). Three prostanoids have been developed to treat PAH: epoprostenol, treprostinil, and iloprost. In the acute setting, experience is growing, using the inhaled forms of these three medications. Inhalation may improve ventilation/perfusion matching, whereas in the intravenous form these medications may cause nonselective pulmonary vasodilation and may worsen ventilation/perfusion matching. Currently, there are no universal recommendations for dosing delivery of inhaled prostanoids to intubated patients in the intensive care unit setting.
前列环素-前列腺素是最早用于治疗肺动脉高压（PAH）的药物之一。已经开发出三种前列腺素来治疗 PAH：依前列醇、曲前列尼尔和伊洛前列素。在急性情况下，使用这三种药物的吸入剂型的经验正在增加。吸入可能改善通气/灌注匹配，而在静脉内形式下，这些药物可能导致非选择性肺血管扩张，并可能使通气/灌注匹配恶化。目前，对于在重症监护病房中插管患者吸入前列腺素的剂量给药，没有通用的建议。
