在重症监护环境中的前列环素。
Prostacyclin in the intensive care setting.
机构信息
Department of Pediatrics, University of Colorado Denver School of Medicine, The Children's Hospital, Aurora, CO, USA.
出版信息
Pediatr Crit Care Med. 2010 Mar;11(2 Suppl):S41-5. doi: 10.1097/PCC.0b013e3181d10845.
Abstract
The prostacyclins-prostanoids were one of the first medications used to treat pulmonary arterial hypertension (PAH). Three prostanoids have been developed to treat PAH: epoprostenol, treprostinil, and iloprost. In the acute setting, experience is growing, using the inhaled forms of these three medications. Inhalation may improve ventilation/perfusion matching, whereas in the intravenous form these medications may cause nonselective pulmonary vasodilation and may worsen ventilation/perfusion matching. Currently, there are no universal recommendations for dosing delivery of inhaled prostanoids to intubated patients in the intensive care unit setting.
摘要
前列环素-前列腺素是最早用于治疗肺动脉高压（PAH）的药物之一。已经开发出三种前列腺素来治疗 PAH：依前列醇、曲前列尼尔和伊洛前列素。在急性情况下，使用这三种药物的吸入剂型的经验正在增加。吸入可能改善通气/灌注匹配，而在静脉内形式下，这些药物可能导致非选择性肺血管扩张，并可能使通气/灌注匹配恶化。目前，对于在重症监护病房中插管患者吸入前列腺素的剂量给药，没有通用的建议。
相似文献
1
Prostacyclin in the intensive care setting.在重症监护环境中的前列环素。
Pediatr Crit Care Med. 2010 Mar;11(2 Suppl):S41-5. doi: 10.1097/PCC.0b013e3181d10845.
2
Inhalation of repurposed drugs to treat pulmonary hypertension.吸入再利用药物治疗肺动脉高压。
Adv Drug Deliv Rev. 2018 Aug;133:34-44. doi: 10.1016/j.addr.2018.06.003. Epub 2018 Jun 8.
3
Parenteral and inhaled prostanoid therapy in the treatment of pulmonary arterial hypertension.肺动脉高压的肠外和吸入性前列环素治疗。
Clin Chest Med. 2013 Dec;34(4):825-40. doi: 10.1016/j.ccm.2013.09.003. Epub 2013 Oct 18.
4
Rapid transition from inhaled iloprost to inhaled treprostinil in patients with pulmonary arterial hypertension.肺动脉高压患者从吸入伊洛前列素快速转换为吸入曲前列尼尔。
Cardiovasc Ther. 2013 Feb;31(1):38-44. doi: 10.1111/1755-5922.12008.
5
Inhaled Therapies for Pulmonary Hypertension.肺动脉高压的吸入疗法
Respir Care. 2015 Jun;60(6):794-802; discussion 802-5. doi: 10.4187/respcare.03927.
6
Cost effectiveness of prostacyclins in pulmonary arterial hypertension.前列腺素类药物治疗肺动脉高压的成本效益。
Appl Health Econ Health Policy. 2012 May 1;10(3):175-88. doi: 10.2165/11630780-000000000-00000.
7
Ventilation/perfusion ratios in pulmonary arterial hypertension: effects of IV and inhaled prostacyclin derivatives.肺动脉高压中的通气/灌注比值：静脉注射和吸入前列环素衍生物的影响
Chest. 2005 Dec;128(6 Suppl):615S-616S. doi: 10.1378/chest.128.6_suppl.615S-a.
8
[Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to pulmonary fibrosis].吸入性前列环素和伊洛前列素治疗继发于肺纤维化的重度肺动脉高压
Pneumologie. 2000 Mar;54(3):133-42. doi: 10.1055/s-2000-9076.
9
Inhaled treprostinil sodium for the treatment of pulmonary arterial hypertension.吸入用前列环素钠治疗肺动脉高压。
Expert Opin Pharmacother. 2011 Nov;12(16):2583-93. doi: 10.1517/14656566.2011.622269.
10
[Role of prostacyclin and its derivatives in the treatment of pulmonary arterial hypertension].前列环素及其衍生物在肺动脉高压治疗中的作用
Medicina (B Aires). 2003;63(3):233-6.
引用本文的文献
1
Current Management and Future Directions for Pulmonary Arterial Hypertension Associated with Congenital Heart Disease.先天性心脏病相关肺动脉高压的当前管理与未来方向
J Pers Med. 2023 Dec 20;14(1):5. doi: 10.3390/jpm14010005.
2
Continuous Prostanoid Initiation in Severe Pulmonary Hypertension in the Pediatric Cardiac Intensive Care Unit.儿科心脏重症监护病房严重肺动脉高压中持续前列环素的启动。
Pediatr Cardiol. 2024 Dec;45(8):1798-1803. doi: 10.1007/s00246-023-03282-y. Epub 2023 Sep 12.
3
Acute Respiratory Distress Syndrome and the Use of Inhaled Pulmonary Vasodilators in the COVID-19 Era: A Narrative Review.急性呼吸窘迫综合征与COVID-19时代吸入性肺血管扩张剂的应用：一篇叙述性综述
Life (Basel). 2022 Nov 2;12(11):1766. doi: 10.3390/life12111766.
4
BREEZE: Open-label clinical study to evaluate the safety and tolerability of treprostinil inhalation powder as Tyvaso DPI™ in patients with pulmonary arterial hypertension.微风研究：一项开放标签的临床研究，旨在评估吸入用曲前列尼尔粉末（商品名Tyvaso DPI™）在肺动脉高压患者中的安全性和耐受性。
Pulm Circ. 2022 Apr 7;12(2):e12063. doi: 10.1002/pul2.12063. eCollection 2022 Apr.
5
Do alterations in pulmonary vascular tone result in changes in central blood volumes? An experimental study.肺血管张力的改变会导致中心血容量的变化吗？一项实验研究。
Intensive Care Med Exp. 2021 Dec 17;9(1):59. doi: 10.1186/s40635-021-00421-8.
6
Drug Treatment of Pulmonary Hypertension in Children.儿童肺动脉高压的药物治疗。
Paediatr Drugs. 2020 Apr;22(2):123-147. doi: 10.1007/s40272-019-00374-2.
7
Prostanoids and their analogues for the treatment of pulmonary hypertension in neonates.前列腺素及其类似物用于治疗新生儿肺动脉高压。
Cochrane Database Syst Rev. 2019 Oct 1;10(10):CD012963. doi: 10.1002/14651858.CD012963.pub2.
8
Inhaled Treprostinil Drug Delivery During Mechanical Ventilation and Spontaneous Breathing Using Two Different Nebulizers.在机械通气和自主呼吸期间使用两种不同雾化器吸入曲前列尼尔的给药情况
Pediatr Crit Care Med. 2017 Jun;18(6):e253-e260. doi: 10.1097/PCC.0000000000001188.
9
Pediatric Cardiac Intensive Care Society 2014 Consensus Statement: Pharmacotherapies in Cardiac Critical Care Pulmonary Hypertension.儿科心脏重症监护学会2014年共识声明：心脏重症监护中肺动脉高压的药物治疗
Pediatr Crit Care Med. 2016 Mar;17(3 Suppl 1):S89-100. doi: 10.1097/PCC.0000000000000622.
10
Use of inhaled iloprost for the management of postoperative pulmonary hypertension in congenital heart surgery patients: review of a transition protocol.吸入伊洛前列素用于先天性心脏病手术患者术后肺动脉高压管理：过渡方案综述
Pediatr Cardiol. 2014 Dec;35(8):1337-43. doi: 10.1007/s00246-014-0933-3. Epub 2014 May 29.
本文引用的文献
1
Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension.用于治疗肺动脉高压的吸入用曲前列尼尔定量气雾剂给药。
Pulm Pharmacol Ther. 2009 Feb;22(1):50-6. doi: 10.1016/j.pupt.2008.11.009. Epub 2008 Nov 30.
2
Advances in prostanoid infusion therapy for pulmonary arterial hypertension.肺动脉高压的前列环素输注疗法进展
J Infus Nurs. 2008 Nov-Dec;31(6):336-45. doi: 10.1097/NAN.0b013e31818c09b1.
3
Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial.在肺动脉高压患者的长期静脉依前列醇治疗中添加西地那非：一项随机试验。
Ann Intern Med. 2008 Oct 21;149(8):521-30. doi: 10.7326/0003-4819-149-8-200810210-00004.
4
Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension.西地那非与吸入性曲前列尼尔联合应用对肺动脉高压血流动力学和气体交换的急性影响
Pulm Pharmacol Ther. 2008 Oct;21(5):824-32. doi: 10.1016/j.pupt.2008.07.003. Epub 2008 Jul 9.
5
Guidelines for the prevention of central venous catheter-related blood stream infections with prostanoid therapy for pulmonary arterial hypertension.肺动脉高压患者使用前列环素治疗时预防中心静脉导管相关血流感染的指南。
Int J Clin Pract Suppl. 2008 Jul(160):5-9. doi: 10.1111/j.1742-1241.2008.01811.x.
6
Comparison of inhaled iloprost and nitric oxide in patients with pulmonary hypertension during weaning from cardiopulmonary bypass in cardiac surgery: a prospective randomized trial.心脏手术体外循环撤机期间吸入伊洛前列素与一氧化氮治疗肺动脉高压患者的比较：一项前瞻性随机试验
J Cardiothorac Vasc Anesth. 2008 Jun;22(3):406-13. doi: 10.1053/j.jvca.2007.10.015. Epub 2008 Jan 22.
7
Prostacyclin therapies for the treatment of pulmonary arterial hypertension.用于治疗肺动脉高压的前列环素疗法。
Eur Respir J. 2008 Apr;31(4):891-901. doi: 10.1183/09031936.00097107.
8
Short- and long-term effects of inhaled iloprost therapy in children with pulmonary arterial hypertension.吸入伊洛前列素治疗儿童肺动脉高压的短期和长期效果。
J Am Coll Cardiol. 2008 Jan 15;51(2):161-9. doi: 10.1016/j.jacc.2007.09.031.
9
Aerosolized iloprost for postoperative pulmonary hypertensive crisis in children with congenital heart disease.雾化吸入伊洛前列素治疗先天性心脏病术后肺动脉高压危象。
Int J Cardiol. 2008 Oct 13;129(3):333-8. doi: 10.1016/j.ijcard.2007.08.084. Epub 2007 Dec 21.
10
Medical therapy for pulmonary arterial hypertension: updated ACCP evidence-based clinical practice guidelines.肺动脉高压的药物治疗：美国胸科医师学会循证临床实践指南（更新版）
Chest. 2007 Jun;131(6):1917-28. doi: 10.1378/chest.06-2674.
Zotero 插件