偏头痛血管研究进展。
An update on the blood vessel in migraine.
机构信息
Department of Neurology, David Geffen School of Medicine at UCLA, California, USA.
出版信息
Curr Opin Neurol. 2010 Jun;23(3):266-74. doi: 10.1097/WCO.0b013e32833821c1.
PURPOSE OF REVIEW
The cranial blood vessel is considered an integral player in the pathophysiology of migraine, but its perceived role has been subject to much discussion and controversy over the years. We will discuss the evolution in our scientific understanding of cranial blood vessels (primarily arteries) in migraine.
RECENT FINDINGS
Recent developments have clarified the role of cranial blood vessels in the trigemino-vascular system and in cortical spreading depression. An underlying theme is the intimate relation between vascular activity and neural function, and we will emphasize the various roles of the blood vessel that go beyond delivering blood. We conclude that migraine cannot be understood, either from a research or clinical point of view, without an understanding of the vascular derangements that accompany it.
SUMMARY
Migraine is accompanied by significant derangements in vascular function that may represent important targets for investigation and treatment.
目的综述
颅脑血管被认为是偏头痛病理生理学中的一个重要组成部分，但多年来，其作用一直存在诸多争议。我们将讨论偏头痛中颅脑血管（主要是动脉）的科学认识的演变。
最近的发现
最近的研究进展阐明了颅脑血管在三叉神经血管系统和皮质扩散性抑制中的作用。一个潜在的主题是血管活动和神经功能之间的密切关系，我们将强调血管的各种作用，这些作用不仅仅是输送血液。我们的结论是，无论从研究还是临床的角度来看，如果不了解伴随偏头痛的血管紊乱，就无法理解偏头痛。
总结
偏头痛伴随着明显的血管功能紊乱，这些紊乱可能是研究和治疗的重要靶点。
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