HIV 感染者中的肥胖：体重对 CD4 细胞计数的影响。
Obesity among HIV-infected persons: impact of weight on CD4 cell count.
机构信息
Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
出版信息
AIDS. 2010 Apr 24;24(7):1069-72. doi: 10.1097/QAD.0b013e328337fe01.
Abstract
To assess the effect of obesity on CD4 cell counts, we estimated the association of time-updated BMI categories with CD4 changes among 1001 documented HIV seroconverters. During the pre-highly active antiretroviral therapy (HAART) era, a higher BMI was associated with less reduction in CD4 cell counts over time. However during the HAART era, obese versus normal weight patients had smaller increases in CD4 cell counts (+69 versus +116 cells, P = 0.01). Lower CD4 cell counts may now be another adverse consequence of obesity.
摘要
为了评估肥胖对 CD4 细胞计数的影响，我们估计了时间更新的 BMI 类别与 1001 名确诊 HIV 感染者中 CD4 变化的关联。在高效抗逆转录病毒治疗（HAART）之前，较高的 BMI 与随着时间的推移 CD4 细胞计数减少较少有关。然而，在 HAART 时代，肥胖患者与正常体重患者相比，CD4 细胞计数的增加幅度较小（+69 与 +116 个细胞，P=0.01）。现在，CD4 细胞计数较低可能是肥胖的另一个不利后果。
相似文献
1
Obesity among HIV-infected persons: impact of weight on CD4 cell count.
AIDS. 2010 Apr 24;24(7):1069-72. doi: 10.1097/QAD.0b013e328337fe01.
2
Impact of weight on immune cell counts among HIV-infected persons.
Clin Vaccine Immunol. 2011 Jun;18(6):940-6. doi: 10.1128/CVI.00020-11. Epub 2011 Apr 27.
3
CD4+ cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression.
Clin Infect Dis. 2007 Feb 1;44(3):441-6. doi: 10.1086/510746. Epub 2006 Dec 20.
4
Treatment with highly active antiretroviral therapy in human immunodeficiency virus type 1-infected children is associated with a sustained effect on growth.
Pediatrics. 2002 Feb;109(2):E25. doi: 10.1542/peds.109.2.e25.
5
Factors influencing increases in CD4 cell counts of HIV-positive persons receiving long-term highly active antiretroviral therapy.
J Infect Dis. 2004 Nov 15;190(10):1860-8. doi: 10.1086/425075. Epub 2004 Oct 8.
6
Immunological and virological responses to highly active antiretroviral therapy in a non-clinical trial setting in a developing Caribbean country.
HIV Med. 2006 Mar;7(2):99-104. doi: 10.1111/j.1468-1293.2006.00347.x.
7
Early postseroconversion CD4 cell counts independently predict CD4 cell count recovery in HIV-1-postive subjects receiving antiretroviral therapy.
J Acquir Immune Defic Syndr. 2011 Aug 15;57(5):387-95. doi: 10.1097/QAI.0b013e3182219113.
8
Continued CD4 cell count increases in HIV-infected adults experiencing 4 years of viral suppression on antiretroviral therapy.
AIDS. 2003 Sep 5;17(13):1907-15. doi: 10.1097/00002030-200309050-00009.
9
Predictive factors for immunological and virological endpoints in Thai patients receiving combination antiretroviral treatment.
HIV Med. 2007 Jan;8(1):46-54. doi: 10.1111/j.1468-1293.2007.00427.x.
10
Diagnostic accuracy of CD4 cell count increase for virologic response after initiating highly active antiretroviral therapy.
AIDS. 2006 Aug 1;20(12):1613-9. doi: 10.1097/01.aids.0000238407.00874.dc.
引用本文的文献
1
Overweight and Obesity Among People Living With HIV on Dolutegravir- and Efavirenz-Based Therapies: A Comparative Cross-Sectional Study.
AIDS Res Treat. 2024 Dec 19;2024:5347620. doi: 10.1155/arat/5347620. eCollection 2024.
2
Evaluation of the effects of Artemisia Annua L. and Moringa Oleifera Lam. on CD4 count and viral load among PLWH on ART at Mbarara Regional Referral Hospital: a double-blind randomized controlled clinical trial.
AIDS Res Ther. 2024 Apr 16;21(1):22. doi: 10.1186/s12981-024-00609-4.
3
Gestational diabetes in women living with HIV in the UK and Ireland: insights from population-based surveillance data.
J Int AIDS Soc. 2023 Apr;26(4):e26078. doi: 10.1002/jia2.26078.
4
High baseline body mass index predicts recovery of CD4+ T lymphocytes for HIV/AIDS patients receiving long-term antiviral therapy.
PLoS One. 2022 Dec 30;17(12):e0279731. doi: 10.1371/journal.pone.0279731. eCollection 2022.
5
Implications of Bariatric Surgery on the Pharmacokinetics of Antiretrovirals in People Living with HIV.
Clin Pharmacokinet. 2022 May;61(5):619-635. doi: 10.1007/s40262-022-01120-7. Epub 2022 Apr 11.
6
Contribution of Adipose Tissue to the Chronic Immune Activation and Inflammation Associated With HIV Infection and Its Treatment.
Front Immunol. 2021 Jun 18;12:670566. doi: 10.3389/fimmu.2021.670566. eCollection 2021.
7
Survival of HIV/AIDS patients treated under ART follow-up at the University hospital, northwest Ethiopia.
Environ Health Prev Med. 2021 Apr 30;26(1):52. doi: 10.1186/s12199-021-00976-8.
8
Relationship between Endothelial Function, Antiretroviral Treatment and Cardiovascular Risk Factors in HIV Patients of African Descent in South Africa: A Cross-Sectional Study.
J Clin Med. 2021 Jan 20;10(3):392. doi: 10.3390/jcm10030392.
9
Association of body mass index with immune recovery, virological failure and cardiovascular disease risk among people living with HIV.
HIV Med. 2021 Apr;22(4):294-306. doi: 10.1111/hiv.13017. Epub 2020 Nov 17.
10
The interaction between detectable plasma viral load and increased body mass index on hypertension among persons living with HIV.
AIDS Care. 2020 Jul;32(7):890-895. doi: 10.1080/09540121.2019.1668521. Epub 2019 Sep 18.
本文引用的文献
1
Obesity and lymphocyte subsets in virologically suppressed HIV-infected patients.
Metabolism. 2009 Sep;58(9):1285-7. doi: 10.1016/j.metabol.2009.04.011. Epub 2009 Jun 18.
2
Obesity among patients with HIV: the latest epidemic.
AIDS Patient Care STDS. 2008 Dec;22(12):925-30. doi: 10.1089/apc.2008.0082.
3
The correlation between adiposity and adiponectin, tumor necrosis factor alpha, interleukin-6 and high sensitivity C-reactive protein levels. Is adipocyte size associated with inflammation in adults?
J Endocrinol Invest. 2007 Mar;30(3):210-4. doi: 10.1007/BF03347427.
4
A tale of 2 epidemics: the intersection between obesity and HIV infection in Philadelphia.
J Acquir Immune Defic Syndr. 2005 Aug 15;39(5):557-61.
5
Overweight and human immunodeficiency virus (HIV) progression in women: associations HIV disease progression and changes in body mass index in women in the HIV epidemiology research study cohort.
Clin Infect Dis. 2003;37 Suppl 2:S69-80. doi: 10.1086/375889.
6
AIDS wasting syndrome: trends, influence on opportunistic infections, and survival.
J Acquir Immune Defic Syndr. 2003 Jun 1;33(2):267-73. doi: 10.1097/00126334-200306010-00024.
7
Overweight and obesity as determinants of cardiovascular risk: the Framingham experience.
Arch Intern Med. 2002 Sep 9;162(16):1867-72. doi: 10.1001/archinte.162.16.1867.
8
Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines.
J Leukoc Biol. 2002 Aug;72(2):330-8.
9
Wasting and obesity in HIV outpatients.
AIDS. 2001 Nov 23;15(17):2341-2. doi: 10.1097/00002030-200111230-00024.
10
T lymphopaenia in relation to body mass index and TNF-alpha in human obesity: adequate weight reduction can be corrective.
Clin Endocrinol (Oxf). 2001 Mar;54(3):347-54.
Zotero 插件