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[N - myc 癌基因及相关基因激活与化疗耐药性、神经母细胞瘤的预后价值]

[Activation of N-myc oncogene and associated genes to chemoresistance, prognostic value for neuroblastoma].

作者信息

Bénard J, Bourhis J, Riou G

机构信息

Laboratoire de pharmacologie clinique et moléculaire, institut Gustave-Roussy, Villejuif, France.

出版信息

Bull Cancer. 1991 Jan;78(1):91-7.

PMID:2021689
Abstract

N-myc amplification and ploïdic index are important prognosis factors in neuroblastoma. Combined overexpression of the multidrug resistance gene, MDR1 and of Glutathion-S-Transferase, GST-pi may be related to the response of tumors to chemotherapy. Measurements of these parameters may contribute to define responders and non-responders to chemotherapy and provide the clinician with additional criteria to manage treatment.

摘要

N-myc扩增和倍体指数是神经母细胞瘤重要的预后因素。多药耐药基因MDR1和谷胱甘肽S-转移酶GST-pi的联合过表达可能与肿瘤对化疗的反应有关。对这些参数的测量可能有助于确定化疗的反应者和无反应者,并为临床医生提供管理治疗的额外标准。

相似文献

1
[Activation of N-myc oncogene and associated genes to chemoresistance, prognostic value for neuroblastoma].[N - myc 癌基因及相关基因激活与化疗耐药性、神经母细胞瘤的预后价值]
Bull Cancer. 1991 Jan;78(1):91-7.
2
Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma.多药耐药相关蛋白(MRP)基因的表达与儿童神经母细胞瘤中N - myc癌基因的扩增及过表达相关。
Cancer Res. 1994 Oct 1;54(19):5036-40.
3
Inverse correlation between expression of multidrug resistance gene and N-myc oncogene in human neuroblastomas.人神经母细胞瘤中多药耐药基因表达与N-myc癌基因之间的负相关。
Cancer Res. 1990 May 15;50(10):3043-7.
4
Expression of multiple drug resistance gene, MDR1, and N-myc oncogene in an Italian population of human neuroblastoma patients.
Anticancer Res. 1990 Jul-Aug;10(4):897-902.
5
Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification.凋亡抑制蛋白bcl-2在神经母细胞瘤中的表达与不良组织学及N-myc扩增相关。
Am J Pathol. 1993 Dec;143(6):1543-50.
6
Lack of correlation of N-myc gene amplification with prognosis in localized neuroblastoma: a Pediatric Oncology Group study.局限性神经母细胞瘤中N-myc基因扩增与预后的不相关性:一项儿科肿瘤学组研究
Cancer Res. 1995 Feb 15;55(4):721-6.
7
[Oncogen N-myc expression and measurement of DNA ploidy in neuroblastoma: a double staining flow cytometric analysis].
Bull Cancer. 1997 Mar;84(3):29-34.
8
Autoregulation of the human N-myc oncogene is disrupted in amplified but not single-copy neuroblastoma cell lines.人类N-myc癌基因的自动调节在扩增的而非单拷贝的神经母细胞瘤细胞系中被破坏。
Oncogene. 1997 Oct 16;15(16):1937-46. doi: 10.1038/sj.onc.1201363.
9
Prognostic value of MDR1 gene expression in neuroblastoma: results of a multivariate analysis.
Prog Clin Biol Res. 1994;385:111-6.
10
Combined analysis of DNA ploidy index and N-myc genomic content in neuroblastoma.神经母细胞瘤中DNA倍体指数与N-myc基因组含量的联合分析
Prog Clin Biol Res. 1991;366:107-13.

引用本文的文献

1
Expression of MDR1/p-glycoprotein and multidrug resistance-associated protein in childhood solid tumours.多药耐药基因1/ P糖蛋白和多药耐药相关蛋白在儿童实体瘤中的表达
Virchows Arch. 1997 Feb;430(2):99-105. doi: 10.1007/BF01008030.