去甲肾上腺素对睡眠中三叉运动神经元的控制：与睡眠呼吸暂停的相关性。

Noradrenergic control of trigeminal motoneurons in sleep: relevance to sleep apnea.

机构信息

Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.

出版信息

Adv Exp Med Biol. 2010;669:281-4. doi: 10.1007/978-1-4419-5692-7_57.

PMID:20217366

Abstract

Using rapid-eye-movement (REM) sleep as a model state, we sought to determine whether noradrenaline functions to strengthen upper airway muscle tone by amplifying glutamatergic excitation on to trigeminal motoneurons. We report that noradrenaline cannot trigger motoneuron excitability on its own, instead acting to facilitate glutamatergic motor excitation.

摘要

我们以快速眼动（REM）睡眠为模型状态，试图确定去甲肾上腺素是否通过放大谷氨酸能对三叉神经运动神经元的兴奋来增强上气道肌肉张力。我们报告说，去甲肾上腺素本身不能触发运动神经元的兴奋性，而是作用于促进谷氨酸能运动兴奋。