Department of Pharmacy, Annamalai University, Annamalai nagar, 608 002, Tamilnadu, India.
J Fluoresc. 2010 Jul;20(4):809-20. doi: 10.1007/s10895-010-0623-3. Epub 2010 Mar 10.
Spectral characteristics of flutamide drug have been studied in various solvents and beta-cyclodextrin (beta-CD). The inclusion complex of flutamide with beta-CD is analysed by UV-visible, fluorimetry, FT-IR, 1H NMR, SEM, DSC and AM1 methods. In all solvents, flutamide exhibits a dual fluorescence. The longer wavelength emission (A band approximately 380 nm) is due to intramolecular charge transfer state (ICT) and the shorter wavelength emission (B band approximately 285 nm) originates from a locally excited state. In beta-CD, the increase in the fluorescence intensity of 'A' band indicates ICT emission enhanced in the beta-CD medium. beta-CD studies shows isopropyl group is present in the interior part of the beta-CD cavity whereas amino and CF(3) groups are present in the outside of the beta-CD cavity. A mechanism is proposed to explain the 1:1 inclusion process.
已在各种溶剂和β-环糊精（β-CD）中研究了氟他胺药物的光谱特性。通过紫外可见光谱法、荧光光谱法、FT-IR、1H NMR、SEM、DSC 和 AM1 方法分析了氟他胺与β-CD 的包合复合物。在所有溶剂中，氟他胺都表现出双重荧光。较长波长的发射（A 带约 380nm）归因于分子内电荷转移态（ICT），而较短波长的发射（B 带约 285nm）源于局部激发态。在β-CD 中，“A”带荧光强度的增加表明 ICT 发射在β-CD 介质中得到增强。β-CD 研究表明异丙基基团存在于β-CD 腔的内部，而氨基和 CF3 基团存在于β-CD 腔的外部。提出了一种机制来解释 1:1 的包合过程。
