Immunogenetic Unit, Faculty of Medicine of Sousse, Sousse, Tunisia.
East Mediterr Health J. 2009 Nov-Dec;15(6):1483-8.
This study determined the prevalence of inherited factor V Leiden mutation in a group of 128 thrombosis patients (102 with venous thrombosis and 26 with arterial thrombosis) attending a hospital in Sousse, Tunisia, and a control group of 100 with no history of thrombosis. Using an allele-specific PCR amplification technique, factor V Leiden was found in significantly more patients (20.3%) than controls (6.0%). The higher prevalence was significant in the subgroup of venous thrombosis patients but not in arterial thrombosis patients. The allele frequency was 3.5% in the normal Tunisian population. Screening Tunisian patients with venous thrombosis and their relatives for factor V Leiden may be justified.
本研究在突尼斯苏塞的一家医院，对 128 名血栓患者（102 例静脉血栓形成患者和 26 例动脉血栓形成患者）和 100 名无血栓形成史的对照组进行了遗传因子 V 莱顿突变的流行率检测。应用等位基因特异性 PCR 扩增技术，在患者中发现因子 V 莱顿突变的明显多于对照组（20.3%比 6.0%）。静脉血栓形成患者亚组的发生率更高，但动脉血栓形成患者中无此差异。在正常突尼斯人群中，该等位基因的频率为 3.5%。对静脉血栓形成患者及其亲属进行因子 V 莱顿突变的筛查可能是合理的。
