Chang R S, Lewis J P, Reynolds R D, Sullivan M J, Neuman J
Ann Intern Med. 1978 Jan;88(1):34-40. doi: 10.7326/0003-4819-88-1-34.
In an attempt to associate oropharyngeal excretion of Epstein-Barr (EB) virus with lymphoproliferative disorders other than infectious mononucleosis, we tested throat gargles collected from adult subjects for the EB virus. Nine (16%) of 55 healthy persons were positive. High EB virus-excretion rates were found among patients with active acute lymphocytic leukemia (6/6, 100%), among renal homograft recipients during the third to 12th month after transplantation (26/30, 87%), and among critically ill patients with leukemia-lymphoma (14/19, 74%). Moderately high excretion rates were found among patients with myeloma (7/16, 44%), patients with poorly differentiated lymphocytic lymphoma (5/11, 44%), critically ill patients with solid cancers (15/37, 41%), and patients with chronic myelogenous leukemia (8/21, 38%). Our data suggested that the higher than normal excretion rate is realted to the basic disease process and to the general health status but not to the duration of cancer chemotherapy.
为了探究爱泼斯坦 - 巴尔（EB）病毒的口咽排泄与传染性单核细胞增多症以外的淋巴增生性疾病之间的关联，我们对成年受试者采集的咽漱液进行了EB病毒检测。55名健康人中9人（16%）呈阳性。在患有活动性急性淋巴细胞白血病的患者中（6/6，100%）、肾移植受者移植后第3至12个月期间（26/30，87%）以及患有白血病 - 淋巴瘤的重症患者中（14/19，74%）发现了较高的EB病毒排泄率。在骨髓瘤患者中（7/16，44%）、低分化淋巴细胞淋巴瘤患者中（5/11，44%）、患有实体癌的重症患者中（15/37，41%）以及慢性粒细胞白血病患者中（8/21，38%）发现了中等偏高的排泄率。我们的数据表明，高于正常的排泄率与基础疾病进程和总体健康状况有关，而与癌症化疗的持续时间无关。
