Iwakawa Hiro-oki, Okuno Testuro
Laboratory of Plant Pathology, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
Uirusu. 2009 Dec;59(2):179-87. doi: 10.2222/jsv.59.179.
Many lines of recent evidence indicate that non-coding RNAs including micro RNAs (miRNAs) and small interfering RNAs (siRNAs) play an important role in the control of gene expression in diverse cellular processes and in defense responses against molecular parasites such as viruses and transposons. Viruses also use many different types of non-coding RNAs for regulating expression of their own genome or host genome temporally and spatially to ensure efficient virus proliferation and/or latency in the host cell. Here, we introduce the generation mechanisms and functions of novel non-coding RNAs generated from both animal and plant RNA viruses, after a brief review of non-coding RNAs of DNA viruses.
最近的许多证据表明,包括微小RNA(miRNA)和小干扰RNA(siRNA)在内的非编码RNA在多种细胞过程中的基因表达调控以及针对病毒和转座子等分子寄生虫的防御反应中发挥着重要作用。病毒也利用许多不同类型的非编码RNA在时间和空间上调节自身基因组或宿主基因组的表达,以确保在宿主细胞中高效的病毒增殖和/或潜伏。在此,在简要回顾DNA病毒的非编码RNA之后,我们介绍了来自动物和植物RNA病毒的新型非编码RNA的产生机制和功能。