[孕妇对白喉、破伤风和百日咳抗体的监测]

[Monitoring of antibodies against diphtheria, tetanus and pertussis in pregnant women].

作者信息

Za'tsev E M, Krasnoproshina L I, Astakhova T I, Zakharova N S

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 2010 Jan-Feb(1):32-5.

PMID:20218342

Abstract

AIM

To assess antibody levels against diphtheria, pertussis, and tetanus in pregnant women.

MATERIALS AND METHODS

One hundred and two virtually healthy pregnant women aged 18-35 years were studied. Antibodies to diphtheria and tetanus were measured in passive hemagglutination reaction with diphtheria and tetanus diagnostic kits. Antibodies to Bordetella pertussis antigens were determined in hemagglutination assay (HA) and in enzyme immunoassay (EIA).

RESULTS

Protective titers of anti-diphtheria and anti-tetanus antibodies were detected in 91.2% and 94.1% of participants respectively, whereas high titers--in 24.5% and 27.4% respectively. Low levels of IgG to B. pertussis antigens measured by EIA were observed in 70.6% of participants whereas moderate and high levels--in 22.5% and 6.9% respectively. Conditionally protective levels of anti-pertussis antibodies measured by HA were detected in 10.8% of participants.

CONCLUSION

Obtained results demonstrate high level of protection of pregnant women against diphtheria and tetanus and low level of anti-pertussis immunity.

摘要

目的

评估孕妇对白喉、百日咳和破伤风的抗体水平。

材料与方法

研究了102名年龄在18 - 35岁的健康孕妇。使用白喉和破伤风诊断试剂盒通过被动血凝反应检测白喉和破伤风抗体。在血凝试验（HA）和酶免疫测定（EIA）中测定百日咳博德特氏菌抗原的抗体。

结果

分别在91.2%和94.1%的参与者中检测到抗白喉和抗破伤风抗体的保护效价，而高滴度分别为24.5%和27.4%。通过EIA测定，70.6%的参与者中观察到针对百日咳博德特氏菌抗原的低水平IgG，而中高水平分别为22.5%和6.9%。通过HA测定，在10.8%的参与者中检测到有条件的抗百日咳抗体保护水平。