通过环氧化物引发的阳离子级联反应的（+）-omaezakianol 的简短全合成。
A short total synthesis of (+)-omaezakianol via an epoxide-initiated cationic cascade reaction.
机构信息
Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA.
出版信息
Org Lett. 2010 Apr 2;12(7):1512-4. doi: 10.1021/ol100213e.
PMID:20218639
Abstract
(+)-Omaezakianol was synthesized in only three steps from racemic chlorohydrin 4 by Shi epoxidation followed by cascade cyclization and reduction.
摘要
（+）-Omaezakianol 可由外消旋氯醇 4 通过 Shi 环氧化反应、级联环化反应和还原反应三步仅以三步合成。
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