Department of Organic Chemistry, Campus Miguel Delibes, University of Valladolid, 47011 Valladolid, Spain.
Departamento de Química Orgánica y Química Inorgánica, Facultad de Farmacia e Instituto de Investigación Química Andrés M. del Río (IQAR), Universidad de Alcalá, Ctra. Madrid-Barcelona, 28871 Madrid, Spain.
Mar Drugs. 2022 Oct 15;20(10):642. doi: 10.3390/md20100642.
Heterocycles are particularly common moieties within marine natural products. Specifically, tetrahydrofuranyl rings are present in a variety of compounds which present complex structures and interesting biological activities. Focusing on terpenoids, a high number of tetrahydrofuran-containing metabolites have been isolated during the last decades. They show promising biological activities, making them potential leads for novel antibiotics, antikinetoplastid drugs, amoebicidal substances, or anticancer drugs. Thus, they have attracted the attention of the synthetics community and numerous approaches to their total syntheses have appeared. Here, we offer the reader an overview of marine-derived terpenoids and related compounds, their isolation, structure determination, and a special focus on their total syntheses and biological profiles.
杂环化合物在海洋天然产物中尤为常见。具体来说，四氢呋喃环存在于各种具有复杂结构和有趣生物活性的化合物中。以萜类化合物为例，在过去几十年中已经分离出了大量含有四氢呋喃的代谢物。它们表现出有希望的生物活性，使它们成为新型抗生素、抗锥虫药物、杀阿米巴物质或抗癌药物的潜在先导化合物。因此，它们引起了合成化学家的关注，并且已经出现了许多针对它们的全合成方法。在这里，我们为读者提供了海洋衍生萜类化合物和相关化合物的概述，包括它们的分离、结构确定，以及特别关注它们的全合成和生物特征。
