García-Borbolla Rafael, García-Borbolla Mariano
Cardiology Department, Hospital General de Jerez, Jerez de la Frontera (Cádiz).
Infect Disord Drug Targets. 2010 Feb;10(1):47-58. doi: 10.2174/187152610790410927.
Previous to the availability of antimicrobial therapy, infective endocarditis (IE) was habitually lethal. Although approximately 80 percent of patients with endocarditis currently survive their infections, one of every six patients with IE does not survive the initial hospitalization, and up to one-third of patients infected with highly virulent organisms (such as Staphylococcus aureus) may die as a direct or indirect result of their valvular infection. An unfavourable outcome in these patients can occur despite having received appropriate antimicrobial therapy in a suitable approach, and despite the expert use of modern diagnostic techniques. Our purpose is to review the main issues related to the antimicrobial therapy.
在抗菌治疗出现之前，感染性心内膜炎（IE）通常是致命的。尽管目前约80%的心内膜炎患者能从感染中存活下来，但每六例IE患者中就有一例在首次住院期间死亡，感染高毒力病原体（如金黄色葡萄球菌）的患者中，多达三分之一可能因瓣膜感染直接或间接死亡。尽管这些患者已采用合适的方法接受了适当的抗菌治疗，且熟练运用了现代诊断技术，但仍可能出现不良结局。我们的目的是回顾与抗菌治疗相关的主要问题。
