CNRS, Alfred Fessard Institute of Neurobiology, Laboratory of Neurobiology and Development, UPR-3294, Signal Transduction and Developmental Neuropharmacology Team, Gif-sur-Yvette, France.
J Neurochem. 2010 May;113(3):576-90. doi: 10.1111/j.1471-4159.2010.06642.x. Epub 2010 Mar 10.
The discovery of a Sonic Hedgehog (Shh) signaling pathway in the mature vertebrate CNS has paved the way to the characterization of the functional roles of Shh signals in normal and diseased brain. Shh is proposed to participate in the establishment and maintenance of adult neurogenic niches and to regulate the proliferation of neuronal or glial precursors in several brain areas. Consistent with its role during brain development, misregulation of Shh signaling is associated with tumorigenesis while its recruitement in damaged neural tissue might be part of the regenerating process. This review focuses on the most recent data of the Hedgehog pathway in the adult brain and its relevance as a novel therapeutic approach for brain diseases including brain tumors.
成熟脊椎动物中枢神经系统中 Sonic Hedgehog (Shh) 信号通路的发现，为研究 Shh 信号在正常和病变大脑中的功能作用奠定了基础。Shh 被认为参与了成年神经发生龛的建立和维持，并调节了几个脑区的神经元或神经胶质前体细胞的增殖。与它在大脑发育过程中的作用一致，Shh 信号的失调与肿瘤发生有关，而它在受损神经组织中的募集可能是再生过程的一部分。这篇综述重点介绍了成年大脑中 Hedgehog 通路的最新数据及其作为治疗包括脑肿瘤在内的脑部疾病的新方法的相关性。
