García Figueiras R, Padhani A R, Vilanova J C, Goh V, Villalba Martín C
Complexo Hospitalario Universitario de Santiago de Compostela, A Coruña, España.
Radiologia. 2010 Mar-Apr;52(2):115-25. doi: 10.1016/j.rx.2009.12.008. Epub 2010 Mar 9.
Most advances in conventional diagnostic imaging techniques have focused on improving the spatial resolution and speed of acquisition of images or on new contrast agents. However, tumors are extremely complex biological models with a series of characteristics like hypoxia, metabolism, cellularity, angiogenesis, and functionality of the lymph nodes that are very important in oncology but cannot be adequately studied with these diagnostic imaging methods. In this article, we discuss the possible contributions of different functional imaging techniques based on computed tomography, magnetic resonance imaging, or positron emission tomography to obtain information about different biological processes and characteristics that are very important for diagnosing, staging, planning treatment, evaluating the response to treatment, and monitoring the evolution of cancer patients, as well as for the development of new drugs.
传统诊断成像技术的大多数进展都集中在提高图像的空间分辨率和采集速度或新型造影剂上。然而，肿瘤是极其复杂的生物学模型，具有一系列特征，如缺氧、代谢、细胞构成、血管生成以及淋巴结功能等，这些在肿瘤学中非常重要，但使用这些诊断成像方法无法充分研究。在本文中，我们讨论基于计算机断层扫描、磁共振成像或正电子发射断层扫描的不同功能成像技术在获取有关不同生物学过程和特征信息方面的可能贡献，这些信息对于癌症患者的诊断、分期、治疗规划、评估治疗反应以及监测病情发展非常重要，同时对于新药研发也很重要。
