Servicio de Radiodiagnóstico, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.
Clin Transl Oncol. 2010 Sep;12(9):606-13. doi: 10.1007/s12094-010-0565-x.
Conventional diagnostic magnetic resonance imaging (MRI) techniques have focused on improving the spatial resolution and image acquisition speed (whole-body MRI) or on new contrast agents. Most advances in MRI go beyond morphologic study to obtain functional and structural information in vivo about different physiological processes of tumor microenvironment, such as oxygenation levels, cellular proliferation, or tumor vascularization through MRI analysis of some characteristics: angiogenesis (perfusion MRI), metabolism (MRI spectroscopy), cellularity (diffusion-weighted MRI), lymph node function, or hypoxia [blood-oxygen-level-dependent (BOLD) MRI]. We discuss the contributions of different MRI techniques than must be integrated in oncologic patients to substantially advance tumor detection and characterization risk stratification, prognosis, predicting and monitoring response to treatment, and development of new drugs.
传统的诊断磁共振成像（MRI）技术主要集中在提高空间分辨率和图像采集速度（全身 MRI）或新型对比剂上。MRI 的大多数进展都超越了形态学研究，通过对一些特征的 MRI 分析，在体内获得关于肿瘤微环境不同生理过程的功能和结构信息，如氧合水平、细胞增殖或肿瘤血管生成[血管生成（灌注 MRI）、代谢（磁共振波谱）、细胞密度（扩散加权 MRI）、淋巴结功能或缺氧（血氧水平依赖（BOLD）MRI）]。我们讨论了不同 MRI 技术的贡献，这些技术必须整合到肿瘤患者中，以大大提高肿瘤检测和特征分析的风险分层、预后、预测和监测治疗反应以及新药开发的水平。
