Ramsey Ian K
Faculty of Veterinary Medicine, University of Glasgow, Bearsden, Bearsden Road Glasgow, Glasgow G61 1QH, UK.
Vet Clin North Am Small Anim Pract. 2010 Mar;40(2):269-83. doi: 10.1016/j.cvsm.2009.10.008.
Over the last 10 years, trilostane, a competitive inhibitor of steroid synthesis, is being widely used for the treatment of canine hyperadrenocorticism. Trilostane causes a significant but reversible decrease in cortisol production and a concomitant improvement in clinical signs in most dogs with this common condition. Side effects, though infrequent, can be serious: dogs treated with this drug require regular monitoring. This review summarizes current knowledge of the use of this drug with particular emphasis on its efficacy, safety, adverse reactions, and effects on endocrine parameters. Brief mention is made of its other uses in dogs and other species.
在过去10年里，曲洛司坦（一种类固醇合成竞争性抑制剂）被广泛用于治疗犬肾上腺皮质功能亢进症。曲洛司坦可使大多数患有这种常见病症的犬的皮质醇分泌显著但可逆地减少，并同时改善临床症状。副作用虽不常见，但可能很严重：使用这种药物治疗的犬需要定期监测。本综述总结了关于该药物使用的现有知识，特别强调了其疗效、安全性、不良反应以及对内分泌参数的影响。简要提及了它在犬和其他物种中的其他用途。
