神经降压素对杏仁核空间学习机制的影响。
Effects of neurotensin in amygdaloid spatial learning mechanisms.
机构信息
Institute of Physiology, Pécs University Medical School, Pécs, Hungary.
出版信息
Behav Brain Res. 2010 Jul 11;210(2):280-3. doi: 10.1016/j.bbr.2010.02.038. Epub 2010 Feb 26.
Neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reward related processes. The central nucleus of amygdala (CeA) participates in the regulation of memory and learning mechanisms. In Morris water maze test, rats were microinjected with NT or neurotensin receptor-1 (NTS1) antagonist SR 48692 (ANT). NT significantly reduced the escape latency. Effect of NT was blocked by ANT pretreatment. Our results show that in the rat CeA NT facilitates spatial learning. We clarified that NTS1s are involved in this action.
神经降压素（NT）作为一种神经递质和/或神经调质，在学习和奖励相关过程中发挥作用。杏仁中央核（CeA）参与调节记忆和学习机制。在 Morris 水迷宫测试中，将 NT 或神经降压素受体-1（NTS1）拮抗剂 SR 48692（ANT）微注射到大鼠中。NT 显著缩短了逃避潜伏期。NT 的作用被 ANT 预处理阻断。我们的结果表明，在大鼠 CeA 中，NT 促进空间学习。我们阐明了 NTS1 参与了这一作用。
Zotero 插件