神经降压素在奖励过程中的作用。
Neurotensin in reward processes.
机构信息
Neuroscience Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
出版信息
Neuropharmacology. 2020 May 1;167:108005. doi: 10.1016/j.neuropharm.2020.108005. Epub 2020 Feb 11.
Neurotensin (NTS) is a neuropeptide neurotransmitter expressed in the central and peripheral nervous systems. Many studies over the years have revealed a number of roles for this neuropeptide in body temperature regulation, feeding, analgesia, ethanol sensitivity, psychosis, substance use, and pain. This review provides a general survey of the role of neurotensin with a focus on modalities that we believe to be particularly relevant to the study of reward. We focus on NTS signaling in the ventral tegmental area, nucleus accumbens, lateral hypothalamus, bed nucleus of the stria terminalis, and central amygdala. Studies on the role of NTS outside of the ventral tegmental area are still in their relative infancy, yet they reveal a complex role for neurotensinergic signaling in reward-related behaviors that merits further study. This article is part of the special issue on 'Neuropeptides'.
神经降压素（NTS）是一种在中枢和外周神经系统中表达的神经肽递质。多年来的许多研究揭示了这种神经肽在体温调节、摄食、镇痛、乙醇敏感性、精神病、物质使用和疼痛中的许多作用。本综述提供了神经降压素作用的一般概述，重点介绍了我们认为与奖励研究特别相关的方式。我们专注于腹侧被盖区、伏隔核、外侧下丘脑、终纹床核和中央杏仁核中的 NTS 信号。腹侧被盖区以外的 NTS 作用的研究仍处于相对初期阶段，但它们揭示了神经降压素能信号在与奖励相关的行为中的复杂作用，值得进一步研究。本文是“神经肽”特刊的一部分。
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