Department of Physiology and Center of Excellence for Perinatology Research, Jessenius Faculty of Medicine, Comenius University, 036 01 Martin, Slovak Republic.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 May 30;34(4):613-8. doi: 10.1016/j.pnpbp.2010.02.023. Epub 2010 Feb 26.
We aimed to study short-term heart rate variability (HRV) as an index of cardiac autonomic control in never-treated major depressive disorder (MDD) adolescent patients using linear and nonlinear analysis.
We have examined 20 MDD girls and 20 healthy age-matched girls at the age of 15 to 18yr. The ECG was recorded in three positions: the 1st supine rest, orthostasis, the 2nd supine position. HRV magnitude was quantified by time and frequency-domain analysis (mean RR interval, SDRR, RMSSD, spectral powers in low [LF] and high frequency [HF] bands). In addition to linear measures, HRV complexity was assessed by nonlinear (symbolic dynamics) indices: normalized complexity index (NCI), normalized unpredictability index (NUPI), and pattern classification measures (0V%, 1V%, 2LV%, 2UV%).
HRV magnitude (RMSSD, SDRR, LF and HF powers) was significantly decreased in MDD group in a supine rest and after posture change. HRV complexity was significantly reduced (lower NCI) in the standing position. Pattern classification analysis revealed significantly higher 0V% and lower 2LV% in MDD group in supine position and orthostasis.
The HRV linear and nonlinear analysis revealed decreased magnitude and complexity of heart rate time series indicating altered neurocardiac regulation in girls with major depression without pharmacotherapy.
使用线性和非线性分析研究未经治疗的青少年重度抑郁症（MDD）患者的短期心率变异性（HRV）作为心脏自主控制的指标。
我们检查了 20 名 MDD 女孩和 20 名年龄匹配的健康女孩，年龄在 15 至 18 岁之间。在三个位置记录心电图：第一个仰卧休息，直立，第二个仰卧位置。通过时间和频域分析（平均 RR 间隔、SDRR、RMSSD、低频 [LF] 和高频 [HF] 带的谱功率）量化 HRV 幅度。除了线性测量外，还通过非线性（符号动力学）指数评估 HRV 复杂性：归一化复杂性指数（NCI）、归一化不可预测性指数（NUPI）和模式分类测量（0V%、1V%、2LV%、2UV%）。
在仰卧休息和姿势改变后，MDD 组的 HRV 幅度（RMSSD、SDRR、LF 和 HF 功率）显着降低。在直立位置，HRV 复杂性显着降低（NCI 较低）。模式分类分析显示，在仰卧位和直立位时，MDD 组的 0V%明显升高，2LV%明显降低。
HRV 线性和非线性分析显示心率时间序列的幅度和复杂性降低，表明未经药物治疗的重度抑郁症女孩的神经心脏调节改变。
