MicroRNAs--靶向与靶标预测。

MicroRNAs--targeting and target prediction.

机构信息

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO-7489 Trondheim, Norway.

出版信息

N Biotechnol. 2010 Jul 31;27(3):243-9. doi: 10.1016/j.nbt.2010.02.016. Epub 2010 Feb 26.

DOI:10.1016/j.nbt.2010.02.016

PMID:20219708

Abstract

MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate many genes by base pairing to sites in mRNAs. The functionality of miRNAs overlaps that of short interfering RNAs (siRNAs), and many features of miRNA targeting have been revealed experimentally by studying miRNA-mimicking siRNAs. This review outlines the features associated with animal miRNA targeting and describes currently available prediction tools.

摘要

微小 RNA（miRNAs）是一类小的非编码 RNA，可以通过与 mRNA 上的位点碱基配对来调节许多基因。miRNAs 的功能与短干扰 RNA（siRNAs）重叠，并且通过研究 miRNA 模拟的 siRNAs，已经从实验上揭示了 miRNA 靶向的许多特征。本综述概述了与动物 miRNA 靶向相关的特征，并描述了当前可用的预测工具。