Lilly Katy Fader
Woodbury Family Practice, Newington, NH 03801, USA.
Curr Sports Med Rep. 2010 Mar-Apr;9(2):103-5. doi: 10.1249/JSR.0b013e3181d405a9.
The role of nonsteroidal antiinflammatory drugs (NSAID) in pain and inflammation has been evaluated in many forms over the last decade. Emerging evidence shows that this class of medications has different effects depending on injury type: bone, ligament, tendon, and muscle. There are no clear guidelines about specific NSAID choice, duration of use, or route of administration. Benefit of therapy must be weighed against the side effects of NSAID, specifically with respect to the gastrointestinal and renal systems. It is clear that the side effect profile changes within the subclasses of NSAID, nonspecific cyclo-oxygenase-1 and 2 (COX-1 and COX-2) inhibitors, and more selective COX-2 inhibitors. Safe and effective alternatives may include topical NSAID and acetaminophen.
在过去十年中，非甾体抗炎药（NSAID）在疼痛和炎症方面的作用已通过多种形式进行了评估。新出现的证据表明，这类药物根据损伤类型（骨骼、韧带、肌腱和肌肉）的不同而产生不同的效果。关于特定NSAID的选择、使用持续时间或给药途径，目前尚无明确的指导原则。必须权衡治疗的益处与NSAID的副作用，特别是在胃肠道和肾脏系统方面。很明显，NSAID的不同亚类（非特异性环氧化酶-1和-2（COX-1和COX-2）抑制剂以及更具选择性的COX-2抑制剂）的副作用情况有所不同。安全有效的替代药物可能包括外用NSAID和对乙酰氨基酚。
