Aärimaa M, Syvälahti E, Ovaska J
Ann Surg. 1978 Jan;187(1):68-72. doi: 10.1097/00000658-197801000-00013.
Peroperative inhibition of insulin release is widely attributed to increased alpha-adrenergic activity. To test this hypothesis serum insulin and glucose concentrations were measured at short intervals in 11 patients who underwent major surgery. Five patients were anesthetized with halothane and six with general anesthesia without halothane. The results were similar in both patient groups; halothane had no effect on insulin. This suggests that suppression of insulin under operations is probably not due to activation of the alpha-adrenergic receptors of the pancreatic beta-cells. The authors propose that suppression of insulin secretion during surgery may be caused by adrenaline, which, in competing for the glucose receptors, insensitizes the pancreatic beta-cells.
术中胰岛素释放受抑制广泛归因于α-肾上腺素能活性增强。为验证这一假说，对11例接受大手术的患者短时间间隔测量血清胰岛素和葡萄糖浓度。5例患者用氟烷麻醉，6例用无氟烷的全身麻醉。两组患者结果相似；氟烷对胰岛素无影响。这表明手术中胰岛素的抑制可能并非由于胰腺β细胞α-肾上腺素能受体的激活。作者提出手术期间胰岛素分泌受抑制可能由肾上腺素引起，肾上腺素竞争葡萄糖受体，使胰腺β细胞不敏感。
