van der Veen Linda, Scholte Arthur, Stokkel Marcel
Department of Cardiology, Division of Nuclear Medicine, Leiden University Medical Centre, The Netherlands.
Nucl Med Commun. 2010 Jul;31(7):617-28. doi: 10.1097/MNM.0b013e328337a99b.
(123)I-meta-iodobenzyl-guanidine ((123)I-MIBG) scintigraphy is used to visualize and quantify the sympathetic nerve activity. Although it has been used since 1980 to identify myocardial innervation, it is not yet regarded a routine sympathetic imaging agent in this respect. The lack of large multicentre studies and the presence of variations in the protocols that are used for planar MIBG acquisition confines the comparability of study results and application of normal values. Therefore, the aim of this study was to assess the variations in mathematical methods that are currently used to quantify the heart-to-mediastinum ratio and washout rate (WOR). In addition, normal values were evaluated in concordance with these methods. A systematic literature search yielded 169 unique manuscripts, of which 30 contained a complete description of the acquisition protocol for planar MIBG acquisition, image analysis and quantification of the parameters. The results indicate not only large variations in mathematical methods, but also in various aspects of the protocols that are used during acquisition. In many manuscripts method-specific normal values were used; however, these values were generally generated from small, single-centre studies. This study stresses the need to produce guidelines to achieve a standardized method for MIBG acquisition, image analysis and methods to quantify parameters.
（123）I-间碘苄胍（（123）I-MIBG）闪烁扫描术用于可视化和量化交感神经活动。尽管自1980年以来它就被用于识别心肌神经支配，但在这方面它尚未被视为常规的交感神经成像剂。缺乏大型多中心研究以及用于平面MIBG采集的方案存在差异，限制了研究结果的可比性和正常值的应用。因此，本研究的目的是评估目前用于量化心纵隔比和洗脱率（WOR）的数学方法的差异。此外，还根据这些方法评估了正常值。系统的文献检索产生了169篇独特的手稿，其中30篇包含了平面MIBG采集、图像分析和参数量化的采集方案的完整描述。结果表明，不仅数学方法存在很大差异，而且采集过程中使用的方案的各个方面也存在差异。在许多手稿中使用了特定方法的正常值；然而，这些值通常来自小型单中心研究。本研究强调需要制定指南，以实现MIBG采集、图像分析和参数量化方法的标准化。
