早产儿胃食管反流后心肺事件的特征。
Characterization of cardiorespiratory events following gastroesophageal reflux in preterm infants.
机构信息
Division of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH 44106, USA.
出版信息
J Perinatol. 2010 Oct;30(10):683-7. doi: 10.1038/jp.2010.27. Epub 2010 Mar 11.
OBJECTIVE
The aim of this study was to characterize cardiorespiratory events in preterm infants after both acid and nonacid gastroesophageal reflux (GER) as detected by pH and multiple intraluminal impedance (MII).
STUDY DESIGN
Twelve hour overnight studies were performed in 71 preterm infants (gestational age 29.4±3.0 weeks, birth weight 1319±496 g). Apnea ≥10 s in duration, bradycardia ≤80 b.p.m. and oxygen desaturation ≤85% that occurred within 30 s after the initiation of GER were classified as associated with GER.
RESULT
A total of 12,957 cardiorespiratory events and 4164 GER episodes were documented. Less than 3% of all cardiorespiratory events were preceded by GER constituting 3.4% of apnea, 2.8% of oxygen desaturation and 2.9% of bradycardia events. GER did not prolong cardiorespiratory event duration or increase severity. In contrast, GER was associated with a shorter duration of oxygen desaturation events (7.8±4.6 vs 6.3±5.6 s, P<0.05).
CONCLUSION
GER is rarely associated with cardiorespiratory events, and has no detrimental effect on cardiorespiratory event duration or severity.
目的
本研究旨在通过 pH 值和多重腔内阻抗（MII）检测，对酸和非酸胃食管反流（GER）后早产儿的心肺事件进行特征描述。
研究设计
对 71 例早产儿（胎龄 29.4±3.0 周，出生体重 1319±496g）进行了 12 小时的过夜研究。GER 发生后 30 秒内持续时间≥10s 的呼吸暂停、心率≤80b.p.m.和氧饱和度下降≤85%的情况被归类为与 GER 相关。
结果
共记录到 12957 次心肺事件和 4164 次 GER 发作。所有心肺事件中，GER 引起的事件不到 3%，占呼吸暂停的 3.4%、氧饱和度下降的 2.8%和心动过缓的 2.9%。GER 并未延长心肺事件的持续时间或增加严重程度。相比之下，GER 与氧饱和度下降事件的持续时间更短（7.8±4.6 与 6.3±5.6 s，P<0.05）。
结论
GER 很少与心肺事件相关，且对心肺事件的持续时间或严重程度没有不利影响。
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