驴乳源人乳强化剂对早产儿胃食管反流的影响与标准强化剂的比较：来自 FortiLat 研究的补充数据。
Effects on Gastroesophageal Reflux of Donkey Milk-Derived Human Milk Fortifier Versus Standard Fortifier in Preterm Newborns: Additional Data from the FortiLat Study.
机构信息
Neonatal Care Unit, Sant'Anna Hospital, Città della Salute e della Scienza, Università degli Studi di Torino, 10126 Turin, Italy.
Institute of Sciences of Food Production, Italian National Research Council, 10126 Turin, Italy.
出版信息
Nutrients. 2020 Jul 18;12(7):2142. doi: 10.3390/nu12072142.
BACKGROUND
Feeding intolerance is a frequent diagnosis in very preterm infants. As seen in the FortiLat trial, human milk fortification with the new donkey milk-derived human milk fortifier (DF) seems to improve feeding tolerance in these infants. The aim of this study was to evaluate the effects of using the DF compared with bovine milk-derived fortifier (BF) on gastroesophageal reflux (GER) in very low birth weight (VLBW) infants.
METHODS
Over a total of 156 preterm infants were enrolled into the FortiLat trial (GA <32 weeks and birth weight <1500 g) and randomized into the BF arm or DF arm, and we selected all infants with clinical signs of GER and cardiorespiratory (CR) symptoms. All the infants underwent CR and multichannel intraluminal impedance and pH (MII/pH) monitoring associated with gastric ultrasound to evaluate GER and gastric emptying time.
RESULTS
10 infants were enrolled, and 5 were in the DF arm. At MII/pH, infants enrolled into the DF arm showed a lower GER frequency than BF arm infants ( = 0.036). Half gastric emptying time was similar in DF and BF arm infants ( = 0.744).
CONCLUSION
The use of donkey-derived human milk fortifier reduced the GER frequency and consequently should be recommended in infants with feeding intolerance.
背景
喂养不耐受是极早产儿的常见诊断。如 FortiLat 试验所见，用人乳来源的新型驴乳强化剂（DF）强化人乳似乎可改善这些婴儿的喂养耐受性。本研究旨在评估与牛乳来源强化剂（BF）相比，使用 DF 对极低出生体重（VLBW）婴儿胃食管反流（GER）的影响。
方法
在总共 156 名早产儿参加的 FortiLat 试验（GA <32 周且出生体重 <1500 g）中，我们将其随机分为 BF 组或 DF 组，并选择所有有 GER 临床症状和心肺（CR）症状的婴儿。所有婴儿均接受 CR 和多通道腔内阻抗和 pH（MII/pH）监测，并结合胃超声评估 GER 和胃排空时间。
结果
共纳入 10 名婴儿，其中 5 名在 DF 组。在 MII/pH 监测中，DF 组婴儿的 GER 频率低于 BF 组婴儿（ = 0.036）。DF 组和 BF 组婴儿的半胃排空时间相似（ = 0.744）。
结论
使用驴乳来源的人乳强化剂可降低 GER 频率，因此应推荐用于喂养不耐受的婴儿。
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