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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Esler M, Eisenhofer G, Dart A, Chin J, Cox H, Lambert G, Jennings G

Alfred Baker Medical Unit, Alfred Hospital, Prahran, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1991 Feb;18(2):67-70. doi: 10.1111/j.1440-1681.1991.tb01408.x.

Radiotracer methods were used to measure the rates of regional release of adrenaline and noradrenaline to plasma in humans. 2. No release of adrenaline could be detected from the heart, lungs, liver and kidneys at rest. 3. With the relatively mild activation of the cardiac sympathetic outflow associated with mental challenge and isometric exercise, cardiac adrenaline release remained undetectable. 4. During supine bicycle exercise, which increased cardiac noradrenaline release 10-20 fold, to a mean value of 128 ng/min, cardiac adrenaline release averaged 1.63 ng/min. 5. Whether neuronal adrenaline release of this degree in the heart is sufficient to facilitate noradrenaline release and to augment sympathetically mediated cardiac responses remains to be tested.

采用放射性示踪剂方法来测量人体中肾上腺素和去甲肾上腺素向血浆的局部释放速率。2. 静息状态下，未检测到心脏、肺、肝脏和肾脏释放肾上腺素。3. 与精神应激和等长运动相关的心脏交感神经轻度激活时，仍未检测到心脏释放肾上腺素。4. 在仰卧位自行车运动期间，心脏去甲肾上腺素释放增加了10 - 20倍，平均值为128 ng/分钟，而心脏肾上腺素释放平均为1.63 ng/分钟。5. 心脏中这种程度的神经元肾上腺素释放是否足以促进去甲肾上腺素释放并增强交感神经介导的心脏反应，仍有待验证。

Esler M, Eisenhofer G, Dart A, Chin J, Cox H, Lambert G, Jennings G

Alfred Baker Medical Unit, Alfred Hospital, Prahran, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1991 Feb;18(2):67-70. doi: 10.1111/j.1440-1681.1991.tb01408.x.

Radiotracer methods were used to measure the rates of regional release of adrenaline and noradrenaline to plasma in humans. 2. No release of adrenaline could be detected from the heart, lungs, liver and kidneys at rest. 3. With the relatively mild activation of the cardiac sympathetic outflow associated with mental challenge and isometric exercise, cardiac adrenaline release remained undetectable. 4. During supine bicycle exercise, which increased cardiac noradrenaline release 10-20 fold, to a mean value of 128 ng/min, cardiac adrenaline release averaged 1.63 ng/min. 5. Whether neuronal adrenaline release of this degree in the heart is sufficient to facilitate noradrenaline release and to augment sympathetically mediated cardiac responses remains to be tested.

采用放射性示踪剂方法来测量人体中肾上腺素和去甲肾上腺素向血浆的局部释放速率。2. 静息状态下，未检测到心脏、肺、肝脏和肾脏释放肾上腺素。3. 与精神应激和等长运动相关的心脏交感神经轻度激活时，仍未检测到心脏释放肾上腺素。4. 在仰卧位自行车运动期间，心脏去甲肾上腺素释放增加了10 - 20倍，平均值为128 ng/分钟，而心脏肾上腺素释放平均为1.63 ng/分钟。5. 心脏中这种程度的神经元肾上腺素释放是否足以促进去甲肾上腺素释放并增强交感神经介导的心脏反应，仍有待验证。