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Synthesis of isotopically labeled epothilones.
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Design, synthesis and biological evaluation of bridged epothilone D analogues.
Org Biomol Chem. 2008 Dec 21;6(24):4542-52. doi: 10.1039/b814823f. Epub 2008 Nov 6.
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Conformational preferences of natural and C3-modified epothilones in aqueous solution.
J Med Chem. 2008 Mar 13;51(5):1469-73. doi: 10.1021/jm7013452. Epub 2008 Feb 14.
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Total synthesis and selective activity of a new class of conformationally restrained epothilones.
Chemistry. 2008;14(2):570-81. doi: 10.1002/chem.200701143.
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Direct synthesis of amides from alcohols and amines with liberation of H2.
Science. 2007 Aug 10;317(5839):790-2. doi: 10.1126/science.1145295.
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The chemistry and biology of epothilones--the wheel keeps turning.
ChemMedChem. 2007 Apr;2(4):396-423. doi: 10.1002/cmdc.200600206.
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Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution.
Angew Chem Int Ed Engl. 2007;46(11):1864-8. doi: 10.1002/anie.200604505.
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The epothilones and related analogues-a review of their syntheses and anti-cancer activities.
Curr Pharm Des. 2005;11(13):1615-53. doi: 10.2174/1381612053764742.
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Much anticipated--the bioactive conformation of epothilone and its binding to tubulin.
Angew Chem Int Ed Engl. 2005 Feb 18;44(9):1298-301. doi: 10.1002/anie.200462241.
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The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography.
Science. 2004 Aug 6;305(5685):866-9. doi: 10.1126/science.1099190.
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The bioactive Taxol conformation on beta-tubulin: experimental evidence from highly active constrained analogs.
Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10006-11. doi: 10.1073/pnas.0403459101. Epub 2004 Jun 28.
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