Dept. of Chemistry, University of Washington, Seattle, WA 98195, USA.
Lab Chip. 2010 Mar 21;10(6):727-33. doi: 10.1039/b919639k. Epub 2010 Jan 4.
This paper describes a technique for rapidly exchanging the solution environment near a surface by displacing laminar flow fluid streams using sudden changes in applied pressure. The method employs off-chip solenoid valves to induce pressure changes, which is important in keeping the microfluidic design simple and the operation of the system robust. The performance of this technique is characterized using simulation and validated with experiments. This technique adds to the microfluidic tool box that is currently available for manipulating the solution environment around biological particles and molecules.
本文描述了一种通过使用施加压力的突然变化来置换层流流体流从而快速改变表面附近溶液环境的技术。该方法采用片外电磁阀来引起压力变化,这对于保持微流控设计简单和系统操作稳健性非常重要。该技术的性能通过模拟进行了表征,并通过实验进行了验证。这项技术增加了当前可用于操作生物颗粒和分子周围溶液环境的微流控工具包。