Department of Obstetrics and Gynecology, Shin-Kong Wu-Ho-Su Memorial Hospital, Shih-Lin District, Taipei, Taiwan.
Arch Gynecol Obstet. 2011 Feb;283(2):335-41. doi: 10.1007/s00404-010-1404-6. Epub 2010 Mar 11.
To evaluate the accuracy of integrated FDG-PET/CT and tumor markers for the depiction of recurrent ovarian carcinoma.
Patients with pathologically proven ovarian cancer, who underwent cytoreductive surgery and 3-6 cycles of adjuvant chemotherapy, were included in this study. They all underwent a thorough physical examination, tumor marker determination, and FDG-PET/CT imaging. The sensitivity, specificity, accuracy, and positive and negative predictive values for the tumor detection with PET/CT versus different tumor markers were performed in relation to the results at histological analysis after second-look surgery or clinical follow-up.
A total of 37 patients underwent FDG-PET/CT scans. Among them, 22 patients underwent exploratory laparotomy and 15 had diagnostic laparoscopy. Overall, 24 patients were documented to have ovarian cancer recurrence after second operation. FDG-PET/CT had sensitivity, specificity, accuracy, and positive and negative predictive values of 100, 85, 94, 92, and 100%, respectively.
Our study has shown that PET/CT is a sensitive tool to assist in the early identification and recurrent ovarian cancer, amenable to secondary cytoreduction.
评估 FDG-PET/CT 与肿瘤标志物联合检测对复发性卵巢癌的诊断准确性。
本研究纳入了经病理证实的卵巢癌患者，这些患者均接受了肿瘤细胞减灭术和 3-6 个周期的辅助化疗。所有患者均接受了全面的体格检查、肿瘤标志物检测和 FDG-PET/CT 影像学检查。根据二次探查手术或临床随访的组织学分析结果，评估了 PET/CT 与不同肿瘤标志物联合检测在肿瘤检测中的敏感性、特异性、准确性、阳性预测值和阴性预测值。
共 37 例患者接受了 FDG-PET/CT 扫描。其中，22 例患者接受了剖腹探查术，15 例患者接受了诊断性腹腔镜检查。总体而言，24 例患者在二次手术后被证实患有卵巢癌复发。FDG-PET/CT 的敏感性、特异性、准确性、阳性预测值和阴性预测值分别为 100%、85%、94%、92%和 100%。
我们的研究表明，PET/CT 是一种辅助早期识别和治疗复发性卵巢癌的敏感工具，可进行二次减瘤术。
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