Suppiah Subapriya, Chang Wing Liong, Hassan Hasyma Abu, Kaewput Chalermrat, Asri Andi Anggeriana Andi, Saad Fathinul Fikri Ahmad, Nordin Abdul Jalil, Vinjamuri Sobhan
Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia, Selangor, Malaysia.
Department of Imaging, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
World J Nucl Med. 2017 Jul-Sep;16(3):176-185. doi: 10.4103/wjnm.WJNM_31_17.
Ovarian cancer (OC) often presents at an advanced stage with frequent relapses despite optimal treatment; thus, accurate staging and restaging are required for improving treatment outcomes and prognostication. Conventionally, staging of OC is performed using contrast-enhanced computed tomography (CT). Nevertheless, recent advances in the field of hybrid imaging have made positron emission tomography/CT (PET/CT) and PET/magnetic resonance imaging (PET/MRI) as emerging potential noninvasive imaging tools for improved management of OC. Several studies have championed the role of PET/CT for the detection of recurrence and prognostication of OC. We provide a systematic review and meta-analysis of the latest publications regarding the role of molecular imaging in the management of OC. We retrieved 57 original research articles with one article having overlap in both diagnosis and staging; 10 articles (734 patients) regarding the role of PET/CT in diagnosis of OC; 12 articles (604 patients) regarding staging of OC; 22 studies (1429 patients) for detection of recurrence; and 13 articles for prognostication and assessment of treatment response. We calculated pooled sensitivity and specificity of PET/CT performance in various aspects of imaging of OC. We also discussed the emerging role of PET/MRI in the management of OC. We aim to give the readers and objective overview on the role of molecular imaging in the management of OC.
卵巢癌（OC）通常在晚期出现，尽管进行了最佳治疗仍频繁复发；因此，准确的分期和再分期对于改善治疗效果和预后至关重要。传统上，OC的分期是使用对比增强计算机断层扫描（CT）进行的。然而，混合成像领域的最新进展使正电子发射断层扫描/计算机断层扫描（PET/CT）和正电子发射断层扫描/磁共振成像（PET/MRI）成为用于改善OC管理的新兴潜在非侵入性成像工具。几项研究支持了PET/CT在OC复发检测和预后方面的作用。我们对有关分子成像在OC管理中的作用的最新出版物进行了系统评价和荟萃分析。我们检索了57篇原创研究文章，其中一篇文章在诊断和分期方面存在重叠；10篇文章（734例患者）涉及PET/CT在OC诊断中的作用；12篇文章（604例患者）涉及OC的分期；22项研究（1429例患者）用于复发检测；13篇文章用于预后和治疗反应评估。我们计算了PET/CT在OC成像各个方面表现的合并敏感性和特异性。我们还讨论了PET/MRI在OC管理中的新兴作用。我们旨在为读者提供关于分子成像在OC管理中的作用的客观概述。
