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[播散性诺卡菌病:诊断挑战]

[Disseminated nocardiosis : Diagnostic challenge].

作者信息

Heyn J, Ozimek A, Grabein B, Heindl B

机构信息

Klinik für Anaesthesiologie, Klinikum der Universität München, Deutschland.

出版信息

Anaesthesist. 2010 Mar;59(3):225-8. doi: 10.1007/s00101-010-1684-z.

Abstract

Nocardiosis is a rarely found bacterial infection in Europe which can particularly affect immunocompromized patients. Localized infections of the dermis and lungs, as well as disseminated infections can be observed. Suspicion of nocardiosis should be reported to the microbiological laboratory so that goal-directed molecular genetic techniques and extended cultivation can be implemented for identification of the causative agent. A multitude of antibiotics can be used for successful therapy but the duration of therapy must be extended over 6-12 months. The mortality of disseminated infections ranges between 15-85% depending on the underlying immune status of the patient. The polymorphic appearance of nocardiosis is described based on the case of an intensive care patient.

摘要

诺卡菌病在欧洲是一种罕见的细菌感染,尤其会影响免疫功能低下的患者。可观察到真皮和肺部的局部感染以及播散性感染。怀疑患有诺卡菌病时应向微生物实验室报告,以便采用针对性的分子遗传学技术和延长培养时间来鉴定病原体。多种抗生素可用于成功治疗,但治疗时间必须延长6至12个月。根据患者潜在的免疫状态,播散性感染的死亡率在15%至85%之间。基于一名重症监护患者的病例描述了诺卡菌病的多形性表现。

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