蛋白质结构数据库。

EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

Methods Mol Biol. 2010;609:59-82. doi: 10.1007/978-1-60327-241-4_4.

Web-based protein structure databases come in a wide variety of types and levels of information content. Those having the most general interest are the various atlases that describe each experimentally determined protein structure and provide useful links, analyses, and schematic diagrams relating to its 3D structure and biological function. Also of great interest are the databases that classify 3D structures by their folds as these can reveal evolutionary relationships which may be hard to detect from sequence comparison alone. Related to these are the numerous servers that compare folds--particularly useful for newly solved structures, and especially those of unknown function. Beyond these there are a vast number of databases for the more specialized user, dealing with specific families, diseases, structural features, and so on.

基于网络的蛋白质结构数据库有各种各样的类型和信息含量水平。最具普遍兴趣的是各种图谱，它们描述了每个通过实验确定的蛋白质结构，并提供与其三维结构和生物学功能相关的有用链接、分析和示意图。同样非常有趣的是那些根据折叠方式对三维结构进行分类的数据库，因为这些数据库可以揭示进化关系，而仅从序列比较中可能很难检测到这些关系。与之相关的是众多比较折叠方式的服务器——这对于新解析的结构，尤其是那些功能未知的结构特别有用。除此之外，还有大量面向更专业用户的数据库，涉及特定家族、疾病、结构特征等等。