Höbarth K, Hofbauer J
Department of Urology, University of Vienna Medical School, Austria.
Eur Urol. 1991;19(2):165-8. doi: 10.1159/000473606.
24-hour urinary citrate excretion was measured in 176 calcium oxalate stone formers and 100 normal controls. A statistically significant difference (p less than 0.03) could be found between the two groups. When stone formers were divided into a group of 69 patients with recurrent calcium urolithiasis (RCU) and a group of 106 patients with a single stone episode, the latter did not differ from the control group, while in RCU a significantly lower citrate excretion compared with controls (p less than 0.005) could be found. Thus, patients with RCU could benefit from alkali citrate prophylaxis. A female-male difference in citrate excretion could not be found in either the control group or stone formers. Recurrent stone formers presented a significantly higher calcium/citrate ratio compared with controls, which would indicate an increased risk for stone formation. The value of routine citrate analysis is limited, however, by the great, variability of citrate levels in stone formers and controls.
对176例草酸钙结石患者和100例正常对照者进行了24小时尿枸橼酸盐排泄量测定。两组之间存在统计学显著差异（p<0.03）。当结石患者分为69例复发性钙尿路结石（RCU）患者组和106例单发结石发作患者组时，后者与对照组无差异，而在RCU组中，与对照组相比，枸橼酸盐排泄量显著降低（p<0.005）。因此，RCU患者可从碱式枸橼酸盐预防中获益。在对照组或结石患者中均未发现枸橼酸盐排泄的性别差异。与对照组相比，复发性结石患者的钙/枸橼酸盐比值显著更高，这表明结石形成风险增加。然而，由于结石患者和对照者中枸橼酸盐水平变化很大，常规枸橼酸盐分析的价值有限。
