Nikkilä M, Koivula T, Jokela H
Department of Clinical Sciences, University of Tampere, Finland.
Eur Urol. 1989;16(5):382-5. doi: 10.1159/000471622.
Citrate is a normal constituent of urine which combines with calcium to form a soluble salt. Urinary citrate excretion was examined in patients with urolithiasis and normal subjects by a specific enzymatic technique. There was a considerable overlap in the urinary citrate excretion between normal subjects and stone-formers, but the citrate-creatinine ratio, the citrate-calcium ratio and the citrate-magnesium-calcium ratio, which were all highly significantly lower (p less than 0.001) in stone-formers than in controls, proved most reliable in discriminating between these groups.
柠檬酸盐是尿液的正常成分，它与钙结合形成可溶性盐。采用特定的酶学技术对尿路结石患者和正常受试者的尿柠檬酸盐排泄情况进行了检测。正常受试者和结石形成者的尿柠檬酸盐排泄量有相当大的重叠，但结石形成者的柠檬酸盐-肌酐比值、柠檬酸盐-钙比值以及柠檬酸盐-镁-钙比值均显著低于对照组（p<0.001），事实证明这些比值在区分这两组人群时最为可靠。
