体外受精后降低双胎妊娠率——选择性单胚胎移植（eSET）。

Reducing twin pregnancy rates after IVF--elective single embryo transfer (eSET).

作者信息

Milne P, Cottell E, Allen C, Spillane H, Vasallo J, Wingfield M

机构信息

Merrion Fertility Clinic, National Maternity Hospital, Holles Street, Dublin 2.

出版信息

Ir Med J. 2010 Jan;103(1):9-11.

PMID:20222385

Abstract

Multiple pregnancy is a major complication of IVF and is associated with increased maternal, fetal and neonatal morbidity. Elective single embryo transfer (eSET) during IVF, rather than the more standard transfer of two embryos (double embryo transfer or DET), has been shown to significantly reduce the multiple pregnancy rate associated with IVF, while maintaining acceptable pregnancy rates. Couples undergoing IVF in 2008 who met good prognostic criteria had eSET performed. Pregnancy and twinning rates were compared with those for similar couples in 2007 who had DET. Couples unsuccessful with a fresh cycle of treatment had subsequent frozen embryo transfer cycles with DET. The cumulative pregnancy rate was similar for each group. However there were no multiple pregnancies in the eSET group, compared to 4 twins of 5 pregnancies in the DET group. 96% of eligible couples agreed to eSET. ESET is successful in and acceptable to good prognosis Irish couples undergoing IVF.

摘要

多胎妊娠是体外受精（IVF）的主要并发症，与孕产妇、胎儿和新生儿发病率增加相关。在IVF过程中进行选择性单胚胎移植（eSET），而非更标准的双胚胎移植（双胚胎移植或DET），已被证明可显著降低与IVF相关的多胎妊娠率，同时维持可接受的妊娠率。2008年符合良好预后标准的接受IVF的夫妇进行了eSET。将妊娠率和双胎率与2007年接受DET的类似夫妇进行比较。新鲜周期治疗未成功的夫妇随后进行了DET冷冻胚胎移植周期。每组的累积妊娠率相似。然而，eSET组没有多胎妊娠，而DET组5次妊娠中有4例双胞胎。96%符合条件的夫妇同意进行eSET。eSET对于接受IVF的预后良好的爱尔兰夫妇是成功且可接受的。