Laboratory of Natural Product Chemistry, Faculty of Science, Kochi University, Akebono-cho, Kochi 780-8520, Japan.
Org Lett. 2010 Apr 2;12(7):1616-9. doi: 10.1021/ol100350w.
A new method for chiral diamine-catalyzed Robinson-type annulation was developed to construct cyclohexenone derivatives bearing a quaternary carbon stereogenic center at the 4-position in high enantiomeric excess. This method was successfully applied to the short synthesis of (+)-sporochnol A.
发展了一种新的手性二胺催化的 Robinson 型环合方法,用于构建在 4-位具有季碳手性中心的环己烯酮衍生物,对映过量高。该方法成功地应用于 (+)-sporochnol A 的短合成。