Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, 345 Lingling Lu, Shanghai 200032, China.
J Org Chem. 2010 Jan 1;75(1):117-22. doi: 10.1021/jo902081w.
Primary-secondary diamine catalysts were used to catalyze the asymmetric Robinson annulation to synthesize multiply substituted fluorinated chiral cyclohexenones with two contiguous stereogenic centers, one of which is a fluorinated quaternary chiral center, with excellent enantioselectivities and diastereoselectivities in moderate to good yields.
采用仲-仲二胺催化剂催化不对称 Robinson 环化反应，合成了具有两个连续立体中心的多取代氟化手性环己烯酮，其中一个为氟化季碳手性中心，具有优异的对映选择性和非对映选择性，中等至良好的收率。
