University of Montreal Health Center, Québec, Canada.
Future Oncol. 2010 Mar;6(3):381-90. doi: 10.2217/fon.10.4.
Digital rectal examination, serum concentration of prostate cancer-specific antigen and transrectal ultrasound-guided biopsies are currently the main diagnostic tools to detect evidence of prostate cancer. Different prostatic biopsy strategies have been proposed in order to achieve an optimal prostate cancer detection rate and an accurate characterization of prostate cancer stage and grade. We examined the role of the number of biopsy cores on prostate cancer detection rates at initial and repeat biopsies. Moreover, we examined the relationship between the number of biopsy cores and the detection of insignificant prostate cancer. Finally, we reviewed the ability of biopsy cores in predicting prostate cancer stage and grade at radical prostatectomy. We relied on a PubMed systematic review of the contemporary English language literature using the terms 'prostate cancer', 'diagnosis', 'transrectal ultrasound' and 'prostate biopsy'.
直肠指检、前列腺癌特异性抗原血清浓度和经直肠超声引导活检目前是检测前列腺癌证据的主要诊断工具。为了达到最佳的前列腺癌检出率，并准确描述前列腺癌的分期和分级，提出了不同的前列腺活检策略。我们研究了在初次和重复活检中活检核心数量对前列腺癌检出率的影响。此外，我们还研究了活检核心数量与检出无意义前列腺癌之间的关系。最后，我们回顾了活检核心在预测根治性前列腺切除术中前列腺癌分期和分级方面的能力。我们依靠在 PubMed 上进行的当代英语文献系统评价，使用了“前列腺癌”、“诊断”、“经直肠超声”和“前列腺活检”等术语。
