Troisi R J, Weiss S T, Parker D R, Sparrow D, Young J B, Landsberg L
Normative Aging Study, Veterans Administration Outpatient Clinic, Boston, Mass.
Hypertension. 1991 May;17(5):669-77. doi: 10.1161/01.hyp.17.5.669.
The hypothesis that dietary intake and obesity stimulate the sympathetic nervous system was investigated in a cross-sectional study of 572 men aged 43-85 years from the Normative Aging Study. Habitus was represented by body mass index, as a measure of overall adiposity, and by the ratio of abdomen-to-hip circumference (abdomen/hip ratio), as a measure of centripetal fat distribution. Sympathetic activity was assessed by measurement of 24-hour urinary norepinephrine excretion. Increased body mass index and total caloric intake were independently associated with increased 24-hour urinary norepinephrine excretion (p = 0.0001 and p = 0.0055, respectively). In addition, mean urinary norepinephrine excretion was higher in subjects classified as either hyperglycemic (serum fasting glucose greater than or equal to 113 mg/dl) and hyperinsulinemic (serum fasting insulin greater than or equal to 19 microIU/ml) (p = 0.0023) or in subjects classified as either hyperglycemic or hyperinsulinemic (p = 0.0063) than the mean urinary norepinephrine excretion in normal subjects. These relations were demonstrated to be independent of age, smoking status, and physical activity. Our results are consistent with the hypothesis that insulin mediates sympathetic stimulation in response to dietary intake and increases sympathetic nervous system activity in the obese.
在一项针对572名年龄在43 - 85岁之间参与标准衰老研究的男性的横断面研究中，对饮食摄入和肥胖刺激交感神经系统这一假设进行了调查。身体状况以体重指数作为总体肥胖程度的衡量指标，以及以腹臀围比作为向心性脂肪分布的衡量指标来表示。通过测量24小时尿去甲肾上腺素排泄量来评估交感神经活动。体重指数增加和总热量摄入增加分别与24小时尿去甲肾上腺素排泄量增加独立相关（分别为p = 0.0001和p = 0.0055）。此外，被分类为高血糖（空腹血清葡萄糖大于或等于113毫克/分升）和高胰岛素血症（空腹血清胰岛素大于或等于19微国际单位/毫升）的受试者，或被分类为高血糖或高胰岛素血症的受试者，其平均尿去甲肾上腺素排泄量高于正常受试者（p = 0.0023和p = 0.0063）。这些关系被证明独立于年龄、吸烟状况和身体活动。我们的结果与以下假设一致，即胰岛素介导了对饮食摄入的交感神经刺激，并增加了肥胖者的交感神经系统活动。
