Matsumoto Yusuke, Miura Tomoyuki, Akari Hirofumi, Goto Yoshitaka, Haga Takeshi
Department of Veterinary Microbiology, University of Miyazaki, Miyazaki, Japan.
J Vet Med Sci. 2010 Aug;72(8):1057-61. doi: 10.1292/jvms.09-0588. Epub 2010 Mar 12.
In vivo Simian Immunodeficiency Virus (SIV) challenge of macaques demonstrated the earlier disappearance of CD4 and CD8 double-positive (DP) T cells than CD4 single-positive T cells, although its mechanism remains unclear. Here we found that peripheral DP T cells were readily induced to express CCR5, a secondary receptor for SIV, by in vitro stimulation with either concanavalin A or anti-CD3/CD28 monoclonal antibodies. Activated DP T cells were more vulnerable to SIV infection, indicating that the ability of DP T cells to readily express CCR5 after activation may hasten DP T cell death by SIV infection in vivo.
猕猴的体内猿猴免疫缺陷病毒（SIV）攻击试验表明，CD4和CD8双阳性（DP）T细胞比CD4单阳性T细胞更早消失，尽管其机制尚不清楚。在这里，我们发现，通过伴刀豆球蛋白A或抗CD3/CD28单克隆抗体进行体外刺激，外周血DP T细胞很容易被诱导表达SIV的辅助受体CCR5。活化的DP T细胞更容易受到SIV感染，这表明DP T细胞在活化后易于表达CCR5的能力可能会加速体内SIV感染导致的DP T细胞死亡。
