1Department of Internal Medicine; and 2Department of Neurology, University of Toledo College of Medicine, Toledo, OH.
Am J Ther. 2013 Nov-Dec;20(6):e703-5. doi: 10.1097/MJT.0b013e3181d56671.
Valproate-associated hyperammonemic coma in adults is a rare complication of valproate therapy and has been previously reported to occur in few days to years after initiation of therapy. We present a case of hyperammonemic coma induced within hours of initiating valproate therapy in a patient with plasma carnitine deficiency.
丙戊酸盐相关性高氨血症昏迷在成人中是丙戊酸盐治疗的罕见并发症，此前有报道称在开始治疗后数天至数年内发生。我们报告了一例在血浆肉碱缺乏症患者中开始丙戊酸盐治疗数小时内发生的高氨血症昏迷病例。
