Retina Service, Wills Eye Institute, Philadelphia, Pennsylvania, USA.
Curr Opin Ophthalmol. 2010 May;21(3):197-202. doi: 10.1097/ICU.0b013e32833866db.
The field of vitreoretinal disease and surgery has seen tremendous growth and innovation in recent years. In view of the latest advances, the present article highlights some of the current trends in vitreoretinal research that promise to be revolutionary in the coming decade.
Pharmacologic vitreolysis may greatly impact the current approach to treatment of various vitreoretinopathies. New methods of drug delivery to the posterior segment either via nanoparticles or sustained-release intravitreal implants may supplant repetitive intravitreal injections. Gene therapy may become more common as the genetic basis of inherited retinal diseases is further elucidated. Stem-cell transplantation and the implantation of artificial retinal prostheses offer promise for long-term sight restoration.
Based on recent advances in ongoing vitreoretinal research, the spectrum of treatable retinal disease is likely to expand significantly in the coming decade, with enormous public health impact, as well as significant changes in the practice patterns of retina specialists worldwide.
近年来，玻璃体视网膜疾病和手术领域取得了巨大的发展和创新。鉴于最新进展，本文重点介绍了玻璃体视网膜研究中的一些当前趋势，这些趋势有望在未来十年带来革命性的变化。
药物性玻璃体溶解术可能会极大地改变目前治疗各种玻璃体视网膜病变的方法。通过纳米颗粒或缓释眼内植入物将药物递送到后节的新方法可能会取代重复的眼内注射。随着遗传性视网膜疾病的遗传基础得到进一步阐明，基因治疗可能会变得更加普遍。干细胞移植和人工视网膜假体的植入为长期视力恢复带来了希望。
基于正在进行的玻璃体视网膜研究的最新进展，在未来十年内，可治疗的视网膜疾病范围可能会显著扩大，这将对公众健康产生巨大影响，同时也将改变全球视网膜专家的实践模式。
